{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:13Z","timestamp":1790787673162,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["134535\/2016\u20102"],"award-info":[{"award-number":["134535\/2016\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Essential oils (EO) from\n                    <jats:italic>Piper marginatum<\/jats:italic>\n                    Jacq. exhibit biological activities dependent on chemical compositions, which vary mainly due to environmental factors. This study investigated the seasonal and regional variation in the chemical composition and antimicrobial activity of EO from\n                    <jats:italic>P. marginatum<\/jats:italic>\n                    leaves collected in three Brazilian regions across four seasons. Sixty compounds were identified, primarily terpenoids and phenylpropanoids. Multivariate analyses revealed seasonal variations and distinguished the Northeast region EO, which contained the isomers pipermargine (3.38%\u201314.56%) and 1,3,5\u2010trimethoxy\u20102\u2010[(\n                    <jats:italic>Z<\/jats:italic>\n                    )\u2010prop\u20101\u2010enyl]benzene (13.47%\u201314.87%)\u2014reported for the first time in EO. The Central\u2010West winter EO exhibited the broadest antimicrobial spectrum, with strong activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (MIC 0.5\u00a0mg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    (MIC 0.5\u00a0mg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), and a bacteriostatic effect against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . All EO inhibited\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , with the Northeast winter EO showing the strongest activity (MIC 0.25\u00a0mg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). This work highlights the importance of studying the chemical and biological variability of\n                    <jats:italic>P. marginatum<\/jats:italic>\n                    EO for potential applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71771","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:09:26Z","timestamp":1790784566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seasonal and Regional Variation of the Chemical Composition and Antimicrobial Activity of Essential Oils From\n                    <i>Piper marginatum<\/i>\n                    Jacq."],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-5509","authenticated-orcid":false,"given":"Rebeca Gabriel","family":"de Camargo","sequence":"first","affiliation":[{"name":"Departamento De Qu\u00edmica Centro Polit\u00e9cnico Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-629X","authenticated-orcid":false,"given":"Marta Cristina Teixeira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro Pluridisciplinar de Pesquisas Qu\u00edmicas Biol\u00f3gicas e Agr\u00edcolas (CPQBA 11) Universidade Estadual de Campinas  Paul\u00ednia S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-5314","authenticated-orcid":false,"given":"Diones","family":"Krinski","sequence":"additional","affiliation":[{"name":"Curso de Ci\u00eancias Biol\u00f3gicas Universidade Do Estado Do Mato Grosso  Tangar\u00e1 da Serra Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-6399","authenticated-orcid":false,"given":"Ana Paula Palaro Klein","family":"Hendges","sequence":"additional","affiliation":[{"name":"Universidade Tecnol\u00f3gica Federal Do Paran\u00e1  Pato Branco Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea Portes","family":"Ferriani","sequence":"additional","affiliation":[{"name":"Departamento De Qu\u00edmica Centro Polit\u00e9cnico Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco de Assis","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento De Qu\u00edmica Centro Polit\u00e9cnico Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita Gilda","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-2892","authenticated-orcid":false,"given":"Beatriz Helena Lameiro de Noronha Sales","family":"Maia","sequence":"additional","affiliation":[{"name":"Departamento De Qu\u00edmica Centro Polit\u00e9cnico Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"59","article-title":"An Emended Description of Piper Cochleatum and a New Species of Piper (Piperaceae) from the Amazonian Slopes of the Colombian Andes","volume":"408","author":"Calder\u00f3n W. 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