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Following the OSMAC approach, the epigenetic modifiers nicotinamide and sodium butyrate (10\u00a0\u00b5M) were added to triplicate liquid cultures of\n                    <jats:italic>Curvularia<\/jats:italic>\n                    sp. G6\u201032, an endophyte of\n                    <jats:italic>Sapindus saponaria<\/jats:italic>\n                    , and the crude extracts were analyzed by UHPLC\u2010MS\/MS with Mzmine 3 processing and GNPS molecular networking. In total, 712 features were detected: 474 common to all treatments, 65 exclusive to the control, and 154 occurring only in the presence of the modifiers (7 nicotinamide, 9 sodium butyrate, 138 both). PCA, ANOVA (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and volcano analysis (Student's\n                    <jats:italic>t<\/jats:italic>\n                    \u2010test,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03) separated the treated cultures from the control. Among 34 putatively identified compounds, diketopiperazines were the most abundant family (15 ionic species), whereas loliolide, \u03b3\u2010linolenic acid and N\u2010(3\u2010hydroxytetradecanoyl)\u2010DL\u2010homoserine lactone illustrate the diversification elicited by both modifiers.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71774","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:21:06Z","timestamp":1790702466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nicotinamide and Sodium Butyrate Double the Pool of Treatment\u2010Exclusive Metabolites in the Endophytic Fungus\n                    <i>Curvularia<\/i>\n                    sp. G6\u201032"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3172-4637","authenticated-orcid":false,"given":"Guilherme Edison Almeida","family":"Pega","sequence":"first","affiliation":[{"name":"Department of Biotechnology Genetics and Cellular Biology State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds Stella Perassolli","family":"Nicchio","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Genetics and Cellular Biology State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9458-7388","authenticated-orcid":false,"given":"Andressa Domingos","family":"Polli","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Genetics and Cellular Biology State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielli Alana Pereira","family":"Valeze","sequence":"additional","affiliation":[{"name":"Department of Chemistry State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8208-0950","authenticated-orcid":false,"given":"\u00c9velin Lemos de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Genetics and Cellular Biology State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Jandaia do Sul Campus Federal University of Parana  Jandaia do Sul Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-7773","authenticated-orcid":false,"given":"Eduardo Cesar","family":"Meurer","sequence":"additional","affiliation":[{"name":"Jandaia do Sul Campus Federal University of Parana  Jandaia do Sul Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5824-8573","authenticated-orcid":false,"given":"D\u00e9bora Cristina","family":"Baldoqui","sequence":"additional","affiliation":[{"name":"Department of Chemistry State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o L\u00facio","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Genetics and Cellular Biology State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-4320","authenticated-orcid":false,"given":"Julio Cesar","family":"Polonio","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Genetics and Cellular Biology State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2022.127148"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13225\u2010011\u20100116\u2010Y"},{"key":"e_1_2_9_4_1","first-page":"164","article-title":"Endophyte\u2010Mediated Modulation of Defense\u2010Related Genes and Systemic Resistance in Withania somnifera (L.) 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