{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174614,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The new azo ligand (E)\u20102\u2010((1\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indol\u20103\u2010yl)diazenyl)benzoic acid (IDB) was synthesized and complexes of Co(III), Zn(II), and Pd(II) were prepared. Elemental analysis, FT\u2011IR,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2011NMR,\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sup>3<\/jats:sup>\n                    C\u2011NMR, UV\u2013vis, mass spectrometry, molar conductivity, magnetic susceptibility, XRD and FE\u2010SEM were used to fully characterize the compounds. The spectroscopic data are consistent with the Co(III) and Zn(II) being coordinated as bidentate N,O\u2010donors, with the azo nitrogen and deprotonated carboxylate oxygen, and with the Pd(II) being square\u2010planar. The Pd(II) complex demonstrated cytotoxic activity against HL\u201160 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 134.4 \u00b5g\/mL) with modest selectivity over normal HdFn fibroblasts (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 164.7 \u00b5g\/mL, selectivity index = 1.23) among the tested complexes. Mechanistically, it significantly decreased malondialdehyde (MDA) levels in both cancer and normal cells, suggesting modulation of oxidative stress. The Pd(II) complex showed high binding affinity with Aurora kinase (Abl T315I mutant, PDB: 2V7A) with hydrogen bond with ASP\u00a0381 and ASN\u00a0322 and \u03c0\u2013H interaction with LEU\u00a0248. The complexes are predicted to have reduced oral bioavailability, but are still good candidates for parenteral use, while the ligand is predicted to have good drug\u2011like properties. Overall, these results indicate that the Pd(II) complex is a promising lead compound for targeted leukemia therapy, but additional in vivo testing is needed.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71775","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:59:51Z","timestamp":1790539191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Characterization, In Vitro and In Silico Investigation of Azo\u2010Based Co(III), Zn(II), and Pd(II) Complexes Against Human Leukemia"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5828-3686","authenticated-orcid":false,"given":"Yareeb J.","family":"Sahar","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science University of Al\u2010Qadisiyah  Diwaniya Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-7853","authenticated-orcid":false,"given":"Abbas F.","family":"Yasir","sequence":"additional","affiliation":[{"name":"Department of Chemistry Education General Directorate in Al\u2010Muthanna  Samawah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-9196","authenticated-orcid":false,"given":"Hussein A. K.","family":"Kyhoiesh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Education General Directorate in Al\u2010Muthanna  Samawah Iraq"},{"name":"Department of Chemistry, College of Science National University of Science and Technology Nasiriyah Dhi Qar Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01122"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"149","article-title":"A Short Review on Structures and Synthesis of Some Heterocyclic Compounds","volume":"14","author":"Shaikh A. 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