{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174708,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study estimated the effect of seasonal variation on the chemical composition and biological activities of\n                    <jats:italic>Artemisia herba\u2010alba<\/jats:italic>\n                    hydroalcoholic extract and essential oil, focusing on antioxidant and tyrosinase inhibitory activities. Chemical profiling was achieved using LC\u2013MS for the extract and GC\u2013MS for the essential oil. Total phenolic and flavonoid contents were estimated by the Folin\u2013Ciocalteu's and aluminium chloride colorimetric assays. Antioxidant activity was evaluated using DPPH, ABTS, phosphomolybdate, and FRAP methods, while tyrosinase inhibition was expressed as IC\n                    <jats:sub>50<\/jats:sub>\n                    values using kojic acid as a positive control. Molecular docking was performed to explore the interactions of the main constituents with the tyrosinase enzyme.\n                  <\/jats:p>\n                  <jats:p>LC\u2013MS analysis identified naringenin, vanillin, luteolin, quercetin, and trans\u2010cinnamic acid as the major compounds across all samples. GC\u2013MS disclosed seasonal variation in essential oil composition; autumn oil contained several unique ingredients, remarkably davana ether 2, while winter oil was characterized by high carvacrol content. The winter essential oil and summer extract exhibited the strongest antioxidant and tyrosinase inhibitory activities. Molecular docking revealed strong binding affinities of vanillin, kojic acid, and carvacrol within the catalytic pocket of tyrosinase, while thujone isomers exhibited weaker but consistent interactions.<\/jats:p>","DOI":"10.1002\/cbdv.71777","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:41:06Z","timestamp":1790538066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seasonal Phytochemical Variation and Bioactivity of\n                    <i>Artemisia herba\u2010alba<\/i>\n                    : Comparative Evaluation of Essential Oils and Phenolic Extracts With Antioxidant, Tyrosinase Inhibitory and In Silico Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6286-1631","authenticated-orcid":false,"given":"Alia","family":"Djekidel","sequence":"first","affiliation":[{"name":"Laboratory of Biological and Agronomic Sciences (LBAS) Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-5153","authenticated-orcid":false,"given":"Boulanouar","family":"Bakchiche","sequence":"additional","affiliation":[{"name":"Laboratory of Biological and Agronomic Sciences (LBAS) Amar Telidji University  Laghouat Algeria"},{"name":"Research Unit on Medicinal Plants Biotechnology Research Center  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadjira","family":"Guenane","sequence":"additional","affiliation":[{"name":"Laboratory of Biological and Agronomic Sciences (LBAS) Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imededdine","family":"Kadi","sequence":"additional","affiliation":[{"name":"Research Unit on Medicinal Plants Biotechnology Research Center  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-0466","authenticated-orcid":false,"given":"Hicham","family":"Gouzi","sequence":"additional","affiliation":[{"name":"Laboratory of Biological and Agronomic Sciences (LBAS) Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-1069","authenticated-orcid":false,"given":"Ilyas","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Tokat Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6025-8298","authenticated-orcid":false,"given":"S\u00fcleyman M.","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques, School of Health Services Igdir University  Igdir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0505-3190","authenticated-orcid":false,"given":"Ramazan","family":"Erenler","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Tokat Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-1937","authenticated-orcid":false,"given":"Mosad A.","family":"Ghareeb","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department Theodor Bilharz Research Institute  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB10.2491"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2012.04.042"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"27","article-title":"Chemical Characterization and Bioactivities Assessment of Artemisia Herba\u2010alba Asso Essential Oil From South\u2010western Algeria","volume":"8","author":"Ouguirti N.","year":"2021","journal-title":"Natural Volatiles and Essential Oils"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X241282821"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.17508\/CJFST.2025.17.1.08"},{"issue":"13","key":"e_1_2_11_7_1","first-page":"1273","article-title":"Antioxidant and Antibacterial Activities of Extracts From Artemisia Herba alba Asso. 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