{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:00:45Z","timestamp":1790787645670,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273847"],"award-info":[{"award-number":["82273847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pancreatic cancer has a dismal prognosis and limited therapeutic options, highlighting an urgent need for effective treatments. Sophoricoside (SOP), a natural isoflavone glycoside, has exhibited anticancer activities in multiple malignancies, including lung cancer, glioblastoma, and hepatocellular carcinoma. We combined cellular assays, network pharmacology, machine learning, and multi\u2010omics to investigate SOP's effects. SOP\u2010inhibited proliferation of MIA PaCa\u20102, SW1990, and PANC\u20101 cells dose\u2010dependently. Network pharmacology revealed 85 overlapping targets enriched in MAPK, apoptosis, and PD\u2010L1\/PD\u20101 pathways. Machine learning and differential expression identified PTPN1 as the core target.\n                    <jats:italic>PTPN1<\/jats:italic>\n                    was markedly upregulated in pancreatic adenocarcinoma, and its high expression correlated with poor survival and immune infiltration. Functional enrichment linked\n                    <jats:italic>PTPN1<\/jats:italic>\n                    to TGF\u2010\u03b2, VEGF, and metabolic reprogramming. Molecular docking suggested a possible binding mode between SOP and PTPN1, involving four predicted hydrogen bonds. SOP reduced\n                    <jats:italic>PTPN1<\/jats:italic>\n                    mRNA, and\n                    <jats:italic>PTPN1<\/jats:italic>\n                    knockdown phenocopied SOP's antiproliferative effect with no additivity upon combination. Collectively, this first report demonstrates that SOP restrains pancreatic cancer cell proliferation, with\n                    <jats:italic>PTPN1<\/jats:italic>\n                    identified as a key functionally required downstream mediator based on integrative computational and functional evidence. This work offers an integrated strategy for mechanistic exploration and highlights\n                    <jats:italic>PTPN1<\/jats:italic>\n                    as a promising therapeutic biomarker and target for pancreatic cancer.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71778","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:12:13Z","timestamp":1790784733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Omics and Computational Pharmacology Approach With Experimental Validation Reveals the Antiproliferative Activity of Sophoricoside Against Pancreatic Cancer"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3398-8864","authenticated-orcid":false,"given":"Peng","family":"Lin","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1340-5779","authenticated-orcid":false,"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Southwest University  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao P. R. 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