{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:49:01Z","timestamp":1791964141239,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Launaea mucronata<\/jats:italic>\n                    has been traditionally used in folk medicine worldwide for managing various diseases. This study investigated the phytochemical composition and biological activities of the hydroethanolic extract of\n                    <jats:italic>L. mucronata<\/jats:italic>\n                    aerial parts. Total phenolic and flavonoid contents were 63.77\u00a0\u00b1\u00a00.21\u00a0mg GAE\/g and 20.91\u00a0\u00b1\u00a01.56\u00a0mg QE\/g, respectively. Phytochemical investigation yielded lupeol (\n                    <jats:bold>1<\/jats:bold>\n                    ) and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sitosterol (\n                    <jats:bold>2<\/jats:bold>\n                    ) from the\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane fraction; ethyl caffeate (\n                    <jats:bold>3<\/jats:bold>\n                    ) and apigenin (\n                    <jats:bold>4<\/jats:bold>\n                    ) from the dichloromethane fraction; apigenin (\n                    <jats:bold>4<\/jats:bold>\n                    ), luteolin (\n                    <jats:bold>5<\/jats:bold>\n                    ), and apigenin\u20107\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucuronide (\n                    <jats:bold>6<\/jats:bold>\n                    ) from the ethyl acetate fraction. Antioxidant capacity, assessed\n                    <jats:italic>via<\/jats:italic>\n                    2,2\u2011diphenyl\u20111\u2011picrylhydrazyl (DPPH, 109.30\u00a0\u00b1\u00a00.75\u00a0mg AAE\/g) and phosphomolybdenum (119.18\u00a0\u00b1\u00a00.93\u00a0mg AAE\/g) assays, was notable. The extract also showed significant antidiabetic potential, inhibiting\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a00.14\u00a0\u00b1\u00a00.005\u00a0mg\/mL) and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a00.23\u00a0\u00b1\u00a00.007\u00a0mg\/mL), with activity comparable to acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a00.07\u00a0\u00b1\u00a00.002\u00a0mg\/mL and 0.09\u00a0\u00b1\u00a00.003\u00a0mg\/mL, respectively).\n                    <jats:italic>In vivo<\/jats:italic>\n                    , alloxan\u2010induced diabetic rats given oral doses (200 and 400\u00a0mg\/kg, 21 days) exhibited significant hypoglycemic effects, moderate insulinotropic activity, antioxidant actions, and histological improvements in key metabolic organs. These findings suggest\n                    <jats:italic>L. mucronata<\/jats:italic>\n                    as a promising natural candidate for further development as an adjunct therapy for diabetes mellitus (DM).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71780","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:32:58Z","timestamp":1791963178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Compounds and Antidiabetic Properties of\n                    <i>Launaea mucronata<\/i>\n                    Hydroethanolic Extract: Phytochemical and Pharmacological Insights"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0442-7234","authenticated-orcid":false,"given":"Amira","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-6337","authenticated-orcid":false,"given":"Dalia","family":"El Amir","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-8932","authenticated-orcid":false,"given":"Maha M.","family":"Abdel\u2010Fattah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-8836","authenticated-orcid":false,"given":"Mohamed A.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-4250","authenticated-orcid":false,"given":"Rabab","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0952-5984","authenticated-orcid":false,"given":"Marwa H. A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/1389557523666230517113936","article-title":"An Insight Into the Combat Strategies for the Treatment of Type 2 Diabetes Mellitus","volume":"24","author":"Chawla G.","year":"2024","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"e_1_2_10_3_1","volume-title":"Antioxidant\u2010Antidiabetic Agents and Human Health","author":"Akinmoladun A. 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