{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:55:09Z","timestamp":1790798109010,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the extraction and concentration of bioactive compounds from annatto seeds by integrating ethanol\u2013water extraction with ultrafiltration technology. The co\u2010extraction of phenolic and carotenoid compounds was achieved by employing a mixture of ethanol and water as solvent. The annatto seed extract presented bixin and total phenolics at concentrations of 1.91\u00a0\u00b1\u00a00.02 and 52.31\u00a0\u00b1\u00a02.45\u00a0mg\u00a0GAE\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    (dry basis), respectively. Subsequent ultrafiltration through a 5\u00a0kDa membrane effectively concentrated the target molecules, with a membrane rejection of 47.53\u00a0\u00b1\u00a00.22% for total phenolic and 97.90\u00a0\u00b1\u00a00.02% for bixin molecules. Initial permeate flux was 28.59\u00a0L\u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0m\n                    <jats:sup>\u22122<\/jats:sup>\n                    , stabilizing at a steady\u2010state flux of 9.26\u00a0L\u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    m\n                    <jats:sup>\u22122<\/jats:sup>\n                    . The observed flux decline was predominantly characterized by a cake formation fouling mechanism at the earlier times of filtration, while the final flux was described by both cake formation and pore blockage mechanisms. This work highlights the potential of membrane technology for producing high\u2010quality annatto extracts, promoting their broader industrial application.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71783","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:58:04Z","timestamp":1790794684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Production of Bixin\u2010Rich Extracts From Annatto Seeds via Ethanol\u2013Water Extraction Integrated With Ultrafiltration Technology"],"prefix":"10.1002","volume":"23","author":[{"given":"Karolyna B.","family":"Miguel","sequence":"first","affiliation":[{"name":"Chemical Engineering Faculty Federal University of Uberlandia, Santa M\u00f4nica  Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicelma Luiz","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Chemical Engineering Faculty Federal University of Uberlandia, Santa M\u00f4nica  Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-907X","authenticated-orcid":false,"given":"Miria Hespanhol Miranda","family":"Reis","sequence":"additional","affiliation":[{"name":"Chemical Engineering Faculty Federal University of Uberlandia, Santa M\u00f4nica  Uberl\u00e2ndia Minas Gerais 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