{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174729,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202355"],"award-info":[{"award-number":["32202355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fungal infestation in crops can greatly reduce both yield and quality. To discover new fungicides, pyrazol\u20105\u2010yl\u2010phenylacetamide derivatives were synthesized by elongating the carbon chain of the lead compound pyrazol\u20105\u2010yl\u2010benzamides. These derivatives were assessed for their effectiveness against fungi. Compound\n                    <jats:bold>C\u201013<\/jats:bold>\n                    displayed significant antifungal activity against\n                    <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>\n                    , with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 2.51\u00a0mg\/L. Additionally, compound\n                    <jats:bold>C\u201016<\/jats:bold>\n                    showed effective antifungal properties against\n                    <jats:italic>Valsa mali<\/jats:italic>\n                    , with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 3.14\u00a0mg\/L. Particularly noteworthy is the superior antifungal efficacy of compound\n                    <jats:bold>C\u201042<\/jats:bold>\n                    against\n                    <jats:italic>Gaeumannomyces graminis<\/jats:italic>\n                    , with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 1.81\u00a0mg\/L, significantly outperforming\n                    <jats:bold>Fluxapyroxad<\/jats:bold>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a021.01\u00a0mg\/L). Molecular docking and SDH enzymatic inhibition assay results provided insights into the potential mechanism of action of compound\n                    <jats:bold>C\u201042<\/jats:bold>\n                    . This study supports the development of pyrazol\u20105\u2010yl\u2010phenylacetamides as promising fungicides, particularly against\n                    <jats:italic>G. graminis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71784","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:05:15Z","timestamp":1790539515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Biological Evaluation of Pyrazol\u20105\u2010yl\u2010Phenylacetamide Derivatives as Potential Fungicidal Agents"],"prefix":"10.1002","volume":"23","author":[{"given":"Guo\u2010Tai","family":"Lin","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-4938","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"School of Agriculture Ningxia University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-8676","authenticated-orcid":false,"given":"Gong","family":"Xu","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-3893","authenticated-orcid":false,"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185383"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18094664"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100521"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5423\/PPJ.OA.03.2018.0038"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03455"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c01260"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300456"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.03.060"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b00325"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4488"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c05646"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO\u201001\u201013\u20100009\u2010RVW"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b11212"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c05702"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c07190"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b05134"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c07322"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5773"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113230"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00748"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b00151"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.060"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2019.02.017"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c06654"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.110912"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00092"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c04708"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03399"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010020\u201010177\u20100"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5463"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202101032"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c08094"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c01901"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202108009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01591"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c06700"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6406"}],"container-title":["Chemistry &amp; 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