{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:56:09Z","timestamp":1792065369283,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The phytochemical composition and biological activities of extracts obtained from the aerial parts (ARA), fruits (ARF), and rhizomes (ARR) of\n                    <jats:italic>Arum rupicola<\/jats:italic>\n                    var.\n                    <jats:italic>rupicola<\/jats:italic>\n                    (Araceae) were investigated using in vitro and in silico approaches. Phenolic and volatile profiles were characterized by HPLC and GC\/MS. Antioxidant (DPPH), antimicrobial (MIC), and cytotoxic (MTT) activities were evaluated. Molecular docking, MM\u2010GBSA, and ADME analyses were performed using Schr\u00f6dinger Maestro. HPLC revealed that rutin (35,001\u00a0\u00b5g\/mL) and coumaric acid (13,145\u00a0\u00b5g\/mL) were the dominant phenolics in ARA, while quercetin (18,256\u00a0\u00b5g\/mL) predominated in ARF. ARA showed the strongest cytotoxic activity against HL\u201060 cells with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 141\u00a0\u00b5g\/mL and a selectivity index of 3.8. The strongest antimicrobial activity was observed in ARR against\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    (MIC: 90\u00a0\u00b5g\/mL). Molecular docking indicated that rutin exhibited high binding affinity toward cancer\u2010related and antimicrobial targets, with docking scores of \u22129.24 and \u22129.32\u00a0kcal\/mol against KRAS G12D and \u03b2\u2010lactamase, respectively. ADME analysis showed that most compounds complied with Lipinski's Rule of Five. These findings highlight the potential of\n                    <jats:italic>A. rupicola<\/jats:italic>\n                    var.\n                    <jats:italic>rupicola<\/jats:italic>\n                    as a source of anticancer and antimicrobial agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71785","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:29:14Z","timestamp":1792063754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological Activities and Phytochemical Composition of\n                    <i>Arum rupicola<\/i>\n                    var.\n                    <i>rupicola<\/i>\n                    : An In Vitro and In Silico Study"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3923-9261","authenticated-orcid":false,"given":"Selim Can","family":"Kamalak","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-7204","authenticated-orcid":false,"given":"Ela Nur","family":"\u015eim\u015fek Sezer","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2833-5710","authenticated-orcid":false,"given":"Erdo\u011fan","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9110258"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ddc3010011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/psr\u20102018\u20100100"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"141","article-title":"Plant Metabolites as New Leads to Anticancer Drug Discovery: Approaches and Challenges","volume":"2","author":"Datir S. 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