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Leaf extracts of\n                    <jats:italic>Corymbia citriodora, Eugenia uniflora<\/jats:italic>\n                    (\n                    <jats:italic>E. uniflora<\/jats:italic>\n                    )\n                    <jats:italic>, Plinia cauliflora<\/jats:italic>\n                    (\n                    <jats:italic>P. cauliflora<\/jats:italic>\n                    )\n                    <jats:italic>, Psidium cattleianum<\/jats:italic>\n                    (\n                    <jats:italic>P. cattleianum<\/jats:italic>\n                    ), and\n                    <jats:italic>Psidium guajava<\/jats:italic>\n                    were characterized by GC\u2013MS and tested at 60\u2013300\u00a0\u00b5g mL\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    for 72\u00a0h. We also performed molecular docking analyses of the identified compounds against two\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    targets, AeSCP\u20102 (PDB: 1PZ4) and AeHKT (PDB: 6MFB), and\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    acetylcholinesterase (DmAChE; PDB: 6XYU), a homologous model of insect AChE. All extracts caused mortality, although responses differed among species.\n                    <jats:italic>P. cattleianum<\/jats:italic>\n                    and\n                    <jats:italic>E. uniflora<\/jats:italic>\n                    were highly active across the tested range, whereas\n                    <jats:italic>P. cauliflora<\/jats:italic>\n                    showed weaker, heterogeneous, and non\u2010monotonic responses. PCA revealed marked compositional differences among species but no significant mortality gradient along the first two components. A grouped cross\u2010validated regression tree showed modest predictive performance, indicating associations between covarying chemical profiles and mortality rather than independent compound effects. Docking against AeSCP\u20102, AeHKT, and DmAChE, followed by molecular dynamics of the AeSCP\u20102\u2013\u03b2\u2010sitosterol complex, identified structurally plausible ligand\u2010target associations. Overall, the study demonstrates species\u2010dependent larvicidal activity and provides experimentally testable hypotheses for prioritizing extracts, compounds, and molecular targets in future investigations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71786","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:16:18Z","timestamp":1790784978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Experimental, Chemometric, and In Silico Analyses of Larvicidal Supercritical Extracts From Myrtaceae Species Against\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-5686","authenticated-orcid":false,"given":"Ubiratan Alegransi","family":"Bones","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences Community University of the Chapec\u00f3 Region \u2013 UNO 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