{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:08Z","timestamp":1791614948401,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer remains a leading cause of mortality worldwide, highlighting the need for novel anticancer agents. Pyrazoline derivatives have attracted considerable interest due to their structural flexibility, enabling modifications, including bioisosteric replacement, to enhance anticancer potential. In this study, eight\n                    <jats:italic>N<\/jats:italic>\n                    \u2010phenylpyrazoline analogs bearing chlorothiophene moieties were synthesized via cyclocondensation of chalcone intermediates with phenylhydrazine, yielding 59%\u201394%. Structural characterization was confirmed using ATR\u2013IR, GC\u2013MS,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010, and\n                    <jats:sup>13<\/jats:sup>\n                    C\u2013NMR analyses. The synthesized derivatives (\n                    <jats:bold>2a\u20102h<\/jats:bold>\n                    ) were assessed for cytotoxicity against the T47D, MCF7, and WiDr cancer cell lines, along with normal Vero cells, using the MTT assay. Selectivity was determined by comparing cytotoxic effects on cancer versus normal cells. Among the compounds, 5\u2010(benzo[d][1,3]dioxol\u20105\u2010yl)\u20103\u2010(5\u2010chlorothiophen\u20102\u2010yl)\u20101\u2010phenyl\u20104,5\u2010dihydro\u20101H\u2010pyrazole (\n                    <jats:bold>2g<\/jats:bold>\n                    ) exhibited the most potent cytotoxicity against WiDr cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a019.63\u00a0\u00b5g\/mL) and the highest selectivity index (SI\u00a0=\u00a0665.88). Molecular docking revealed strong binding affinities of compound\n                    <jats:bold>2g<\/jats:bold>\n                    to COX\u20102 (\u221210.5\u00a0kcal\/mol), supported by favorable pharmacokinetic properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71787","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:14:58Z","timestamp":1791612898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chlorothiophene\u2010Substituted\n                    <i>N<\/i>\n                    \u2010Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX\u20102 Inhibition"],"prefix":"10.1002","volume":"23","author":[{"given":"Nikma Farismatur","family":"Riza","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fia Fathiana","family":"Wulan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3278-061X","authenticated-orcid":false,"given":"Tegar Asanda","family":"Ghifari","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endang","family":"Astuti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-2848","authenticated-orcid":false,"given":"Tutik Dwi","family":"Wahyuningsih","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cCancer \u201d 2022 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cancer."},{"key":"e_1_2_10_3_1","unstructured":"J.Ferlay M.Ervik F.Lam et al. 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