{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:05:30Z","timestamp":1790820330575,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J01387"],"award-info":[{"award-number":["2022J01387"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Verrucosispora<\/jats:italic>\n                    sp. FIM06025 was an actinomycete isolated from marine sponge sample collected from the East China Sea. Three new compounds, including two rare cyclopropane\u2010containing compounds, verrucacrylic acids A and B (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), and a new amino acid derivative, methyl\n                    <jats:italic>N<\/jats:italic>\n                    \u2010[(2\n                    <jats:italic>S<\/jats:italic>\n                    )\u20102\u2010methylbutanoyl]\u2010\n                    <jats:italic>D<\/jats:italic>\n                    \u2010tyrosinate (\n                    <jats:bold>3<\/jats:bold>\n                    ), were isolated from\n                    <jats:italic>Verrucosispora<\/jats:italic>\n                    sp. FIM06025. Compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    were structurally elucidated on the basis of extensive spectroscopic data analysis using 1D\u2010 and 2D\u2010NMR, ECD, and HRESIMS. At a concentration of 100 \u00b5M, compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exhibited inhibitory rates of 28.6% and 45.2% against T47D cells, respectively, and 30.3% and 47.1% against HL60 cells, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71788","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:41:42Z","timestamp":1790818902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Verrucacrylic Acids A and B From a Marine Sponge\u2010derived\n                    <i>Verrucosispora<\/i>\n                    sp. FIM06025"],"prefix":"10.1002","volume":"23","author":[{"given":"Minghong","family":"Chen","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-6036","authenticated-orcid":false,"given":"Chengzeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6367-8818","authenticated-orcid":false,"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural Products as Sources of New Drugs Over the 30 Years From 1981 to 2010","volume":"75","author":"Newman D. 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