{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:00:40Z","timestamp":1790787640192,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The current study aims to assess the potential relevance of the successive fractions,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane and ethyl acetate (EtOAc) of\n                    <jats:italic>Convolvulus althaeoides<\/jats:italic>\n                    in cancer management. Our study demonstrated significant in vitro cytotoxic activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.8, 2.5, and 2.8 for EtOAc and 7.1, 5.3, and 5.3\u00a0\u00b5g\/mL for\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane against HepG\u20102, MCF\u20107, and HCT\u2010116, respectively, comparable to doxorubicin (4.8, 5.6, and 6.5\u00a0\u00b5g\/mL), with a higher IC\n                    <jats:sub>50<\/jats:sub>\n                    against normal human cell line. EtOAc and\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane fractions exhibited substantial antioxidant using DPPH (97.22% and 90.12%, respectively) and moderate anti\u2010inflammatory properties by HRBC method (34.95% and 41.9%, respectively). LC\u2010ESI\u2010MS\/MS analysis of EtOAc fraction revealed 41 peaks with varied chemical structures, indicating its richness of phenolic compounds. GC\u2010MS of\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane fraction indicated an abundance of noteworthy fatty acids, phytol, and phytosterols. The in silico results showed good pharmacophore features and docking scores for some of the identified compounds on ERR\u20103 (quercetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010pentoside \u221211.497), microtubule (rutin \u221210.801), and tubulin (quercetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucoside \u22127.113).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71792","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:06:36Z","timestamp":1790784396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Convolvulus althaeoides<\/i>\n                    as a Potential Natural Source in Cancer Prophylaxis and Treatment: LC\u2010ESI\u2010MS\/MS, GC\u2010MS, In Vitro, and In Silico Investigations"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-2326","authenticated-orcid":false,"given":"Ahmed R.","family":"Hassan","sequence":"first","affiliation":[{"name":"Medicinal and Aromatic Plants Department Desert Research Center  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa Negm","family":"El\u2010Dein","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy (Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany M.","family":"Korkor","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy (Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourelhoda F.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy (Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3933-1442","authenticated-orcid":false,"given":"Ahmed A. M. A.","family":"Selim","sequence":"additional","affiliation":[{"name":"Medicinal and Aromatic Plants Department Desert Research Center  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jcrpr.2017.07.001","article-title":"Review of Cancer From Perspective of Molecular","volume":"4","author":"Hassanpour S. 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