{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:51:19Z","timestamp":1791287479364,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The anti\u2010inflammatory activity of\n                    <jats:italic>Cotula cinerea<\/jats:italic>\n                    essential oil (EO) was evaluated using integrated chemical, in vivo, histological, and computational approaches. Gas chromatography\u2013mass spectrometry (GC\u2013MS) identified trans\u2010thujone (51.86%), santolina triene (10.60%), and sabinene (6.17%) as the most abundant constituents. In benzylthiouracil (BTU)\u2010treated Wistar rats, EO administration reduced the liver and kidney indices from 4.36% to 2.70% and from 0.65% to 0.52%, respectively; red blood cell count increased from 4.90 to 7.17 \u00d7 10\n                    <jats:sup>12<\/jats:sup>\n                    \/L and hemoglobin from 9.40 to 15.40\u00a0g\/dL. Aspartate aminotransferase decreased from 226.06 to 111.10\u00a0U\/L and alanine aminotransferase from 116.00 to 71.56\u00a0U\/L. C\u2010reactive protein and renal markers also moved toward control values, and histological examination showed improved liver and kidney architecture. Computational analyses were used as hypothesis\u2010generating complements to the experimental findings. Molecular docking predicted the most favorable cyclooxygenase\u20102 (COX\u20102) scores for cis\u2010verbenyl acetate (CVA; \u22127.01\u00a0kcal\/mol) and camphor (CAM; \u22126.66\u00a0kcal\/mol). Molecular dynamics (MD) trajectories and molecular mechanics\/Poisson\u2013Boltzmann surface area (MM\u2010PBSA) estimates indicated persistent simulated interactions, with COX\u20102 binding free energies of \u221243.67 \u00b1 3.80 and \u221239.93 \u00b1 2.59\u00a0kcal\/mol, respectively. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) outputs were favorable for CVA and CAM but remain predictive.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71793","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:58:35Z","timestamp":1791284315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Activity of\n                    <i>Cotula cinerea<\/i>\n                    Essential Oil: Integrated Chemical, In Vivo, Histological, and Computational Evaluation"],"prefix":"10.1002","volume":"23","author":[{"given":"Habiba","family":"Haddad","sequence":"first","affiliation":[{"name":"Faculty of Technology Department of Process Engineering and Petrochemistry Laboratory of Valorisation and Technology of Saharian Resources (VTRS) University of El Oued  El Oued Algeria"},{"name":"Department of Physical Sciences Higher Normal School of 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Technology Department of Process Engineering and Petrochemistry Laboratory of Valorisation and Technology of Saharian Resources (VTRS) University of El Oued  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-8973","authenticated-orcid":false,"given":"Salah","family":"Neghmouche Nacer","sequence":"additional","affiliation":[{"name":"Faculty of Exact Sciences Department of Chemistry University of El Oued  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-2547","authenticated-orcid":false,"given":"Elhafnaoui","family":"Lanez","sequence":"additional","affiliation":[{"name":"Faculty of Technology Department of Process Engineering and Petrochemistry Laboratory of Valorisation and Technology of Saharian Resources (VTRS) University of El Oued  El Oued 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