{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:48:58Z","timestamp":1792068538824,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To develop new insecticides to solve the problem of pests, a series of imidazo[4,5\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]pyridine compounds containing iodine were synthesized through the active fragment splicing method. These compounds were characterized by proton nuclear magnetic resonance (\n                    <jats:sup>1<\/jats:sup>\n                    H NMR), carbon\u201013 nuclear magnetic resonance (\n                    <jats:sup>13<\/jats:sup>\n                    C NMR), and high\u2010resolution mass spectrometry (HRMS). The preliminary bioassay results indicated that most of the synthesized compounds exhibited excellent insecticidal activity against\n                    <jats:italic>Plutella xylostella<\/jats:italic>\n                    (\n                    <jats:italic>P. xylostella<\/jats:italic>\n                    )\n                    <jats:italic>, Mythimna separata<\/jats:italic>\n                    (\n                    <jats:italic>M. separata<\/jats:italic>\n                    ), and\n                    <jats:italic>Aphis craccivora<\/jats:italic>\n                    (\n                    <jats:italic>A. craccivora<\/jats:italic>\n                    ). Especially,\n                    <jats:bold>10a<\/jats:bold>\n                    and\n                    <jats:bold>12a<\/jats:bold>\n                    showed outstanding insecticidal activity against\n                    <jats:italic>P. xylostella<\/jats:italic>\n                    ,\n                    <jats:italic>M. separata<\/jats:italic>\n                    , and\n                    <jats:italic>A. craccivora<\/jats:italic>\n                    , which was superior to oxazosulfyl. Meanwhile, the structure\u2013activity relationship was preliminarily discussed. The work demonstrated that the prepared compounds containing imidazo[4,5\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]pyridine and iodine could provide certain hints by structural optimization for the development of new insecticides.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71795","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:04:28Z","timestamp":1792065868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Insecticidal Activity of Imidazo[4, 5\u2010\n                    <i>b<\/i>\n                    ]pyridine Compounds Containing Iodine"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6149-1829","authenticated-orcid":false,"given":"Xufu","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Resources and Environment Hunan Nonferrous Metals Vocational and Technical College  Zhuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Xiang","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lv","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Yao","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5620-8141","authenticated-orcid":false,"given":"Pengmian","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7474-0855","authenticated-orcid":false,"given":"Minhua","family":"Liu","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1747","article-title":"Genomic Adaptation to Polyphagy in Spodoptera Exigua","volume":"1","author":"Cheng T.","year":"2017","journal-title":"Nature Ecology & Evolution"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39868-y","article-title":"Synthesis and Insecticide Evaluation of Some New Oxopropylthiourea Compounds as Insect Growth Regulators Against the Cotton Leafworm, Spodoptera littoralis","volume":"13","author":"El\u2010Saghier A. M.","year":"2023","journal-title":"Scientific Reports"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/ps.6084","article-title":"Status and Outlook for Acaricide and Insecticide Discovery","volume":"77","author":"Jeschke P.","year":"2021","journal-title":"Pest Management Science"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.napere.2024.100103","article-title":"Effective and Eco\u2010Friendly Botanical Insecticidal Agents Against Spodoptera frugiperda (Noctuidae: Lepidoptera) Using the Essential Oil of Stevia rebaudiana","volume":"10","author":"El\u2010Solimany E. A.","year":"2024","journal-title":"Journal of Natural Pesticide Research"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bmc.2015.08.008","article-title":"Broflanilide: A Meta\u2010Diamide Insecticide With a Novel Mode of Action","volume":"24","author":"Nakao T.","year":"2016","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1021\/acs.jmedchem.5c00302","article-title":"Cell\u2014Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds With Diverging Parasitological Profiles Against the Human Malaria Parasite Plasmodium Falciparum","volume":"68","author":"Dam J.","year":"2025","journal-title":"Journal of Medicinal Chemistry"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1021\/acs.oprd.0c00028","article-title":"Development of an Efficient Synthetic Process for Broflanilide","volume":"24","author":"Luo C.","year":"2020","journal-title":"Organic Process Research & Development"},{"key":"e_1_2_9_9_1","unstructured":"M.Liu D.Deng J.Liu et\u00a0al. \u201cAn Amine Compound and Its Preparation Method and Application \u201dCN202411047791. 3A. 2024\u201008\u201001."},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1584\/jpestics.32.278","article-title":"Mechanisms of Action of Insecticides on Ligand\u2010Gated Ion Channels","volume":"32","author":"Ihara M.","year":"2007","journal-title":"Journal of Pesticide Science"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"13249","DOI":"10.1021\/jacs.3c02669","article-title":"Iodinene Nanosheet\u2010to\u2010Iodine Molecule Allotropic Transformation for Antibiosis","volume":"145","author":"You Y.","year":"2023","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_9_12_1","first-page":"5","article-title":"Research and Development of the Novel Insecticide Cyproflanilide","volume":"43","author":"Liu J.","year":"2021","journal-title":"World Pesticides"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/molecules29112668","article-title":"Imidazopyridine Family: Versatile and Promising Heterocyclic Skeletons for Different Applications","volume":"29","author":"Volpi G.","year":"2024","journal-title":"Molecules"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/cbdd.13832","article-title":"Design, Synthesis and Biological Evaluation of Benz\u2010Fused Five\u2010Membered Heterocyclic Compounds as Tubulin Polymerization Inhibitors with Anticancer Activities","volume":"97","author":"Komuraiah B.","year":"2021","journal-title":"Chemical Biology & Drug Design"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.17344\/acsi.2018.4719","article-title":"Synthesis and Characterization of Novel Five Membered Heterocycles and Their Activity against Candida Yeasts","volume":"66","author":"Tawfeeq H. M.","year":"2019","journal-title":"Acta Chimica Slovenica"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1584\/jpestics.J25-02","article-title":"Development of the Insecticide Oxazosulfyl","volume":"50","author":"Ito M.","year":"2025","journal-title":"Journal of Pesticide Science"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1584\/jpestics.R07-02","article-title":"Environmental Fate and Toxicology of Fipronil","volume":"32","author":"Gunasekara A. S.","year":"2007","journal-title":"Journal of Pesticide Science"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/ps.1616","article-title":"Applied Aspects of Neonicotinoid Uses in Crop Protection","volume":"64","author":"Elbert A.","year":"2008","journal-title":"Pest Management Science"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pestbp.2015.11.007","article-title":"No Cross\u2010Resistance Between Imidacloprid and Pymetrozine in the Brown Planthopper: Status and Mechanisms","volume":"130","author":"Yang Y.","year":"2016","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1584\/jpestics.D23-057","article-title":"Insecticidal Activity Against Rice Pest of Oxazosulfyl, a Novel Sulfyl Insecticide","volume":"49","author":"Kamezaki M.","year":"2024","journal-title":"Journal of Pesticide Science"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1021\/acs.jafc.0c04617","article-title":"Oxazosulfyl, a Novel Sulfyl Insecticide, Binds to and Stabilizes the Voltage\u2010Gated Sodium Channels in the Slow\u2010Inactivated State","volume":"69","author":"Suzuki T.","year":"2021","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202500514","article-title":"Design, Synthesis, and Insecticidal Activities of Imidazo[4,5\u2010b]pyridine Compounds Containing Amino Fragment","volume":"22","author":"Yao Y.","year":"2025","journal-title":"Chemistry & Biodiversity"},{"key":"e_1_2_9_23_1","first-page":"1","article-title":"Design, Synthesis, and Insecticidal Activities of Imidazo[4,5\u2010b]pyridine Compounds Containing Uracil Fragment","volume":"63","author":"Sun M.","year":"2026","journal-title":"Journal of Heterocyclic Chemistry"},{"key":"e_1_2_9_24_1","first-page":"1","article-title":"Synthesizing Novel Imidazole\u2014Conjugated Cyclic Sulfone Derivatives with Amide Fragments and Evaluating Their Insecticidal Activities","volume":"62","author":"Wu D.","year":"2025","journal-title":"Journal of Heterocyclic Chemistry"},{"key":"e_1_2_9_25_1","unstructured":"M.Liu L.Zhou L.Lv et\u00a0al. \u201cA Compound Containing Uracil Sulfone and Its Preparation Method and Application \u201d CN2025100072582 A. 2025\u201008\u201001."},{"key":"e_1_2_9_26_1","first-page":"0048","article-title":"A Novel Class of Insecticidal Alkylsulfones are Potent Inhibitors of Vesicular Acetylcholine Transport","volume":"201","author":"Goodchilda J.","year":"2024","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1603\/0022-0493(2007)100[215:ROSCBT]2.0.CO;2","article-title":"Resistance of Some Cultivated Brassicaceae to Infestations by Plutella xylostella (Lepidoptera: Plutellidae)","volume":"100","author":"Sarfraz M.","year":"2007","journal-title":"Journal of Economic Entomology"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:04:31Z","timestamp":1792065871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cbdv.71795"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71795","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71795"}}