{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:50:34Z","timestamp":1792068634060,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274178"],"award-info":[{"award-number":["82274178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sacha Inchi shell (SIS) is the fruit shell of Sacha Inchi (SI), a perennial woody vine belonging to the Euphorbiaceae family and native to the Amazon tropical rainforest region. Due to its various pharmacological effects such as antioxidant, anti\u2010inflammatory, and immune modulation, it has also attracted the attention of numerous scholars. We characterized and identified the Sacha Inchi shell water extract (SISWE) using UHPLC\u2010Q\u2010Exactive\u2010Orbitrap\/MS technology. A total of 44 compounds were identified, which 30 components were detected in SISWE for the first time. We investigated the anti\u2010inflammatory and immunomodulatory effects of SISWE via using the normal RAW264.7 macrophage model and LPS\u2010induced inflammatory macrophage model. The research results indicated that SISWE enhanced the immune response by promoting the phagocytic ability, production of NO, TNF\u2010\u03b1, and IL\u20106 in normal RAW264.7 cells, suppressed the excessive release of NO, IL\u20106, and TNF\u2010\u03b1 in LPS stimulated RAW264.7 cells, decreased the expression level of iNOS protein, and markedly inhibited the phosphorylation of p65, ERK, and JNK, demonstrating good immune regulatory effects. In this study, we demonstrated the bidirectional immunomodulatory function of SISWE. These findings highlight the therapeutic potential of SISWE for both immunodeficiency\u2010related diseases and immune hyperactivation\u2010related disorders.<\/jats:p>","DOI":"10.1002\/cbdv.71796","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:15:21Z","timestamp":1792066521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Component Analysis Based on UHPLC\u2010Q\u2010Exactive\u2010Orbitrap\/MS and Immune Regulatory Activity Assessment by an LPS\u2010Stimulated Macrophages Model of Sacha Inchi Shell (\n                    <i>Plukenetia volubilis<\/i>\n                    Linneo) Extract"],"prefix":"10.1002","volume":"23","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Sino\u2013Pakistan Center on Traditional Chinese Medicine School of Basic Medical Sciences China\u2013Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province School of Basic Medical Sciences Hunan University of Medicine  Huaihua Hunan P. 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