{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:55:24Z","timestamp":1790798124869,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Medicinal plants are valuable sources of bioactive compounds with potential applications in neurodegenerative disorders. This study investigated the antioxidant, neuropharmacological, and monoamine oxidase (MAO) inhibitory activities of\n                    <jats:italic>Ligustrum sinense<\/jats:italic>\n                    (\n                    <jats:italic>L. sinense<\/jats:italic>\n                    ) leaf extract through in vitro, in vivo, and in silico approaches. Antioxidant activity assessed by the DPPH assay demonstrated moderate free radical scavenging capacity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 73.56 \u00b1 2.18 \u00b5g\/mL) compared with\n                    <jats:sc>l<\/jats:sc>\n                    \u2010ascorbic acid (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 7.29 \u00b1 2.86 \u00b5g\/mL). Behavioral evaluations using the open field, hole cross, elevated plus maze, and hole board tests revealed no significant sedative effects at 200 and 400\u00a0mg\/kg, while dose\u2010dependent anxiolytic\u2010like activity was observed through increased exploratory and head\u2010dipping behaviors. Computational analyses, including molecular docking, ADMET profiling, PASS prediction, and molecular dynamics (MD) simulations, identified several phytocompounds with notable affinity toward MAO\u2010A and MAO\u2010B, key therapeutic targets in Parkinson's disease (PD). CID\u201091697556 exhibited the strongest interaction with MAO\u2010B (\u221210.478\u00a0kcal\/mol), whereas CID\u2010519540 showed dual inhibitory potential against MAO\u2010A (\u22126.901\u00a0kcal\/mol) and MAO\u2010B (\u22128.978\u00a0kcal\/mol). These compounds demonstrated favorable pharmacokinetic properties and stable protein\u2013ligand interactions. Collectively,\n                    <jats:italic>L. sinense<\/jats:italic>\n                    shows promising neuropharmacological potential and may represent a natural source for future PD\u2010related drug discovery, warranting further experimental validation and bioactive compound isolation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71799","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:59:18Z","timestamp":1790794758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Neuropharmacological Potential of\n                    <i>Ligustrum sinense<\/i>\n                    Relevant to Parkinson's Disease: In Vivo and In Silico Study"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9119-5017","authenticated-orcid":false,"given":"Sowmitro","family":"Das","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology &amp; Bioinformatics Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4393-7692","authenticated-orcid":false,"given":"S. M. Istiaque","family":"Hamim","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Al\u2010Sultan Abdullah  Kuantan Pahang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-6665","authenticated-orcid":false,"given":"Md Nazmul Hasan","family":"Zilani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Sneha","family":"Chhando","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Al\u2010Sultan Abdullah  Kuantan Pahang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puza","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Zoology Government Brajalal College  Khulna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Ridoy","family":"Hossain","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology &amp; Bioinformatics Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5775-2010","authenticated-orcid":false,"given":"Md.","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology &amp; Bioinformatics Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8255-4335","authenticated-orcid":false,"given":"Jebin","family":"Tasmin","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-0837","authenticated-orcid":false,"given":"Roney","family":"Miah","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Al\u2010Sultan Abdullah  Kuantan Pahang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-1129","authenticated-orcid":false,"given":"Md. 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