{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:50Z","timestamp":1790787710281,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two new 3,4\u2010\n                    <jats:italic>seco<\/jats:italic>\n                    \u2010ergostane\u2010type steroidal saponins (\n                    <jats:bold>1<\/jats:bold>\n                    \u00a0and\u00a0\n                    <jats:bold>2<\/jats:bold>\n                    ) were isolated from the fermentation products of the fungus\u00a0\n                    <jats:italic>Xylaria necrophora<\/jats:italic>\n                    \u00a0SZSS1\u20102\u20102, together with four known compounds: 2\u2010hexylidene\u20103\u2010methylsuccinic acid (\n                    <jats:bold>3<\/jats:bold>\n                    ), xylcarpin C (\n                    <jats:bold>4<\/jats:bold>\n                    ), (24\n                    <jats:italic>R<\/jats:italic>\n                    )\u201022,23\u2010dihydroxy\u2010ergosta\u20104,6,8(14)\u2010trien\u20103\u2010one 23\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010D\u2010glucopyranoside (\n                    <jats:bold>5<\/jats:bold>\n                    ), and 5\u2010carboxymellein (\n                    <jats:bold>6<\/jats:bold>\n                    ). The structures and absolute configurations of the new compounds were elucidated by comprehensive spectroscopic analyses, electronic circular dichroism (ECD), and GIAO\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sup>3<\/jats:sup>\n                    C NMR computational methods, and chemical hydrolysis followed by derivatization to determine the D\u2011mannose configuration of the sugar moiety. All isolated compounds (\n                    <jats:bold>1\u20136<\/jats:bold>\n                    ) were evaluated for their biological activities. Only compound\u00a0\n                    <jats:bold>5<\/jats:bold>\n                    \u00a0showed selective inhibitory activity, inhibiting BV2 microglial cells with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 17.10\u00a0\u00b1\u00a04.18\u00a0\u00b5M. Additionally, none of the compounds exhibited antimicrobial activity against the tested microorganisms.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71800","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:18:18Z","timestamp":1790785098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mannosylxylarinols A and B, Two New 3,4\u2010\n                    <i>Seco<\/i>\n                    \u2010ergostane\u2010type Steroidal Saponins From the Fungus\n                    <i>Xylaria necrophora<\/i>\n                    SZSS1\u20102\u20102"],"prefix":"10.1002","volume":"23","author":[{"given":"Qian","family":"Luo","sequence":"first","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"},{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Fang","family":"Tan","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"},{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ying","family":"Wei","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-8121","authenticated-orcid":false,"given":"Er\u2010Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Institutional Center for Shared Technologies and Facilities Institute of Microbiology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-1428","authenticated-orcid":false,"given":"Li\u2010Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-8651","authenticated-orcid":false,"given":"You\u2010Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-1508","authenticated-orcid":false,"given":"Chang\u2010Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"},{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11274-016-2174-5","article-title":"Secondary Metabolites of Endophytic Xylaria Species With Potential Applications in Medicine and Agriculture","volume":"33","author":"Mac\u00edas\u2010Rubalcava M. 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