{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:03:52Z","timestamp":1790820232023,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mercurialis annua L<\/jats:italic>\n                    . (Euphorbiaceae) is traditionally used to treat renal disorders, although its nephroprotective activity remains poorly documented. This study characterized the phytochemical profile of the Moroccan hydroethanolic extract by UHPLC\u2013ESI\/MS, evaluated its acute toxicity, and investigated its protective effect against cyclophosphamide\u2010induced nephrotoxicity in rats. UHPLC\u2013ESI\/MS tentatively identified phenolic and flavonoid constituents, including isorhamnetin derivatives, taxifolin, epicatechin, and hydro\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid hexoside. No mortality or treatment\u2010related toxicity was observed up to 5000\u00a0mg\/kg. Oral administration of the extract (200 and 400\u00a0mg\/kg) significantly reduced serum creatinine, blood urea nitrogen, kidney weight, and malondialdehyde levels while restoring superoxide dismutase and peroxidase activities. Histopathological examination confirmed marked attenuation of renal damage, particularly at 400\u00a0mg\/kg. These findings provide the first phytochemical characterization of Moroccan\n                    <jats:italic>M. annua<\/jats:italic>\n                    and support its potential as a safe natural nephroprotective agent through antioxidant\u2010related mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71802","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:42:37Z","timestamp":1790818957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Analysis of Moroccan\n                    <i>Mercurialis annua<\/i>\n                    L. and Its Nephroprotective Activity: Evidence Supporting Traditional Renal Uses"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7204-489X","authenticated-orcid":false,"given":"Abdeljalil","family":"Elmahdaoui","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology Neurobiology, Anthropology and Environment Department of Biology Faculty of Sciences Semlalia University Cadi Ayyad  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Zefzoufi","sequence":"additional","affiliation":[{"name":"Team of Bioorganic Chemistry Faculty of Sciences University Choua\u00efb Doukkali  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lansine","family":"Diakit\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology Neurobiology, Anthropology and Environment Department of Biology Faculty of Sciences Semlalia University Cadi Ayyad  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Haida","sequence":"additional","affiliation":[{"name":"Water, Biodiversity and Climate Change Laboratory Faculty of Sciences Semlalia Cadi Ayyad University  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-9642","authenticated-orcid":false,"given":"Rabiaa","family":"Fdil","sequence":"additional","affiliation":[{"name":"Team of Bioorganic Chemistry Faculty of Sciences University Choua\u00efb Doukkali  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-0579","authenticated-orcid":false,"given":"Aziz","family":"Auhmani","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Chemistry Unit of Organic Synthesis and Physico\u2010Molecular Chemistry Department of Chemistry Faculty of Sciences Semlalia University Cadi Ayyad  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Sokar","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology Neurobiology, Anthropology and Environment Department of Biology Faculty of Sciences Semlalia University Cadi Ayyad  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.23876\/j.krcp.21.037","article-title":"Nephrotoxicity of Cancer Therapeutic Drugs: Focusing on Novel Agents","volume":"40","author":"Hong M.","year":"2021","journal-title":"Kidney Research and Clinical Practice"},{"key":"e_1_2_11_3_1","first-page":"37","article-title":"Kidney Stones","volume":"3","author":"Hornberger B.","year":"2018","journal-title":"PA Clinics"},{"issue":"6","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/ndt\/gfw338","article-title":"Nephrotoxicity of Anticancer treatment","volume":"32","author":"Ma\u0142yszko J.","year":"2016","journal-title":"Nephrology, Dialysis, Transplantation\u00a0: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jcc.27280","article-title":"Insights on Cyclophosphamide Metabolism and Anticancer Mechanism of Action: A Computational Study","volume":"45","author":"Dabbish E.","year":"2024","journal-title":"Journal of Computational Chemistry"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1177\/09603271221132140","article-title":"Ameliorative Effect of Herbacetin Against Cyclophosphamide\u2010induced Nephrotoxicity in Rats via Attenuation of Oxidative Stress, Inflammation, Apoptosis and Mitochondrial Dysfunction","volume":"41","author":"Ijaz M. 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