{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:52:51Z","timestamp":1791287571454,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Extraction of the roots of\n                    <jats:italic>Tripterygium wilfordii<\/jats:italic>\n                    afforded ten undescribed dihydro\u2010\u03b2\u2010agarofuran derivatives [tripterdines M\u2010V (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>10<\/jats:bold>\n                    )], including five sesquiterpene polyesters and five sesquiterpene pyridine alkaloids, along with three known analogues (\n                    <jats:bold>11<\/jats:bold>\n                    \u2013\n                    <jats:bold>13<\/jats:bold>\n                    ). Through HRESIMS, spectroscopic analysis (UV, IR, ECD, and 1D\/2D NMR), x\u2011ray crystallography, CD exciton chirality method, and ECD calculations, the structures of these undescribed compounds were elucidated. Four human cancer cell lines (SK\u2010MEL\u20102, HCC1806, HUH\u20107, and PANC\u20101) and one human normal cell line (MRC\u20105) were used to screen all compounds for in vitro cytotoxicity via the CCK\u20108 method. Among the tested cell lines, SK\u2011MEL\u20112 was the most sensitive toward undescribed compounds\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    , giving IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 8.50, 13.30, and 13.28\u00a0\u00b5M, respectively. Notably, these active compounds displayed no obvious cytotoxicity against normal MRC\u20115 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    &gt;50\u00a0\u00b5M).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71803","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:10:31Z","timestamp":1791285031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic Dihydroagarofuran Sesquiterpenoids Isolated From the Roots of\n                    <i>Tripterygium wilfordii<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6533-1384","authenticated-orcid":false,"given":"Ya\u2010Lin","family":"Hu","sequence":"first","affiliation":[{"name":"Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and Bioengineering Hunan Institute of Science and Engineering  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ping","family":"Xie","sequence":"additional","affiliation":[{"name":"Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and Bioengineering Hunan Institute of Science and Engineering  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and Bioengineering Hunan Institute of Science and Engineering  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and Bioengineering Hunan Institute of Science and Engineering  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and Bioengineering Hunan Institute of Science and Engineering  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and Bioengineering Hunan Institute of Science and Engineering  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Analysis of Complex Effects of Proprietary Chinese Medicine Hunan Provincial Key Laboratory  Yongzhou China"},{"name":"Hunan TimesSun Pharmaceutical Co., Ltd  Yongzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo\u2010Dong","family":"Qin","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for Health Aquaculture and Product Processing in Dongting Lake Area Hunan University of Arts and Science  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b601473a"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np500280x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202000471"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ00703J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104247"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.04.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300759u"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200493t"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2020.1803290"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1903460"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2016.1247810"},{"key":"e_1_2_9_13_1","unstructured":"Dictionary 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