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(VTDB) is not only used as an important Tibetan medicine but is also consumed as a common wild vegetable. Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation and progressive destruction of cartilage and bone. VTDB is recorded in the\n                    <jats:italic>Four Medical Classics<\/jats:italic>\n                    for treating \u201cHuang\u2010Shui,\u201d a condition resembling RA. To preliminarily investigate its potential therapeutic basis, VTDB and its polarity\u2010based fractions were evaluated for their effects against RA. The chemical constituents of VTDB\u2010TE were profiled using UHPLC\u2010Q\u2010Orbitrap MS\/MS, and network pharmacology analysis predicted possible involvement of the PI3K\/Akt and JAK2\/STAT3 signaling pathways. Among the tested fractions, VTDB\u2010nBuOH exhibited the most pronounced pharmacological activity in the collagen\u2010induced arthritis (CIA) rat model. VTDB\u2010nBuOH treatment was associated with reduced paw swelling, lower serum levels of rheumatoid factor (RF) and C\u2010reactive protein (CRP), and improved synovial histopathology. The treatment was also associated with reduced levels of pro\u2010inflammatory cytokines and alterations in the levels of proteins associated with PI3K\/Akt, JAK2\/STAT3, and the downstream IKK\/I\u03baB\/NF\u2010\u03baB axis. Additionally, VTDB\u2010nBuOH treatment was associated with a shift in macrophage polarization markers toward an anti\u2010inflammatory M2\u2010like phenotype, suggesting a possible restoration of the M1\/M2 balance within the joint microenvironment. 16S rRNA sequencing revealed VTDB\u2010nBuOH treatment\u2010associated changes in gut microbial composition, including enrichment of certain beneficial genera and reduction of some pathogenic taxa. Proteomic analysis also pointed to the PI3K\/Akt pathway as a potential node of interest. Collectively, these correlative findings suggest that VTDB\u2010nBuOH may alleviate synovial inflammation and cartilage and bone damage through multi\u2010pathway modulation, though further mechanistic studies are needed to establish causality. VTDB\u2010nBuOH shows preliminary promise for further investigation as a potential candidate for RA treatment.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71805","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:06:53Z","timestamp":1791871613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Effects of\n                    <i>Vicatia thibetica<\/i>\n                    De Boiss. in Rheumatoid Arthritis and Associated Multi\u2010Pathway Modulation In Vivo"],"prefix":"10.1002","volume":"23","author":[{"given":"Mo\u2010Zi\u2010Li","family":"Adu","sequence":"first","affiliation":[{"name":"College of Medicine and Health Science &amp; School of Life Science and Technology Wuhan Polytechnic University  Wuhan China"},{"name":"College of History, Culture and Tourism Mianyang Teachers\u2019 College  Mianyang China"},{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Wei","family":"Xia","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En","family":"Yuan","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3912-2204","authenticated-orcid":false,"given":"Yue\u2010Zhi","family":"Tan","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu\u2010Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Preparation Room Fengcheng\u00a0Hospital\u00a0of Traditional Chinese Medicine  Fengcheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-9765","authenticated-orcid":false,"given":"Guo\u2010Yue","family":"Zhong","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine &amp; Laboratory Service Center Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-3664","authenticated-orcid":false,"given":"Qin\u2010Ge","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Science &amp; School of Life Science and Technology Wuhan Polytechnic University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-4478","authenticated-orcid":false,"given":"Rong\u2010Rui","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Science &amp; School of Life Science and Technology Wuhan Polytechnic University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207326666230531144220"},{"key":"e_1_2_12_3_1","first-page":"1228","article-title":"Acute and Subacute Toxicity Study of Extracts From Roots and Leaves of Vicatia thibetica De Boiss","volume":"32","author":"Zhan D.","year":"2020","journal-title":"Natural Product Research and Development"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119384"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117910"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202305197"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1331486"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119754"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr2024718"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1556359"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154462"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118736"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8205"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303167"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010021\u201000585\u20103"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.828920"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157167"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119637"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.799602"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-981-99-7626-3_12","volume-title":"Nanomedicine in Treatment of Diseases","author":"Fatima S. 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