{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:37Z","timestamp":1791614977930,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the present study, bioactive lignans from\n                    <jats:italic>Zanthoxylum armatum<\/jats:italic>\n                    fruits have been investigated for their anti\u2010inflammatory properties and evaluated using dendritic cell\u2010based immunological assays and network pharmacology. The ethyl acetate fraction was subjected to bioassay\u2010guided fractionation, chromatography, and HPLC to isolate pure compounds, characterised by NMR, LC\u2010QTOF\u2010MS, and single\u2010crystal x\u2010ray diffraction. Biological activities were evaluated using DPPH\/ABTS radical scavenging assays, albumin denaturation and haemolysis inhibition assays, and flow cytometric analysis of IL\u201012p40\/70 and CD80 expression in CpG\u2010stimulated MuTuDC1940 dendritic cells. Sesamin exhibited the strongest antioxidant activity, while sesamin and fargesin showed notable anti\u2010inflammatory effects. In CpG\u2010stimulated MuTuDC1940 cells, sesamin reduced the proportion of IL\u201012\u2010positive cells from 63.85% in the CpG\u2010treated group to 52.67%, whereas fargesin (63.23%) showed little change and eudesmin (65.88%) showed a slight increase. Nevertheless, intracellular IL\u201012 MFI was significantly reduced by eudesmin, sesamin, and fargesin compared with CpG stimulation (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01), suggesting modulation of IL\u201012 expression intensity rather than a uniform reduction in the IL\u201012\u2010positive cell population. Network pharmacology, PPI, GO, and KEGG analyses indicated involvement of PI3K\u2013Akt, NF\u2010\u03baB, JAK\u2013STAT, toll\u2010like receptor, Rap1, and VEGF signalling pathways. These findings suggest these compounds may serve as potential natural therapeutics for inflammatory and immune\u2010mediated diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71806","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:19:06Z","timestamp":1791613146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Phytochemical, Immunological, and Network Pharmacology Investigation of Anti\u2010Inflammatory Lignans From\n                    <i>Zanthoxylum armatum<\/i>\n                    Fruits"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-325X","authenticated-orcid":false,"given":"Ningthoujam Indrajit","family":"Singh","sequence":"first","affiliation":[{"name":"BRIC\u2010Institute of Bioresources and Sustainable Development  Imphal Manipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-1754","authenticated-orcid":false,"given":"Salam Pradeep","family":"Singh","sequence":"additional","affiliation":[{"name":"BRIC\u2010Institute of Bioresources and Sustainable Development  Imphal Manipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayan","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"BRIC\u2010Institute of Life Sciences  Bhubaneshwar Orissa India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-7777","authenticated-orcid":false,"given":"Chingakham Brajakishor","family":"Singh","sequence":"additional","affiliation":[{"name":"BRIC\u2010Institute of Bioresources and Sustainable Development  Imphal Manipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010100311\u2010102839"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1359\u20106101(03)00043\u20101"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059\u2010012\u20100128\u20109"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37080"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521999201230200503"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117245"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.11.004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26134023"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1855646"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.42"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1687789"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1321051"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010023\u201000768\u20101"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.10.020"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116031"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13360"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010021\u201002512\u2010z"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415482"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2023.09.008"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr\u201024\u2010972"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000828\u20105"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010024\u201003102\u2010x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1596802"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26115372"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.021"}],"container-title":["Chemistry &amp; 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