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UHPLC\u2011MS\/MS analysis revealed that the major compounds in the tested extracts are protocatechuic aldehyde, caffeic acid, cynaroside, and cosmosiin. The data demonstrated that the dichloromethane fraction was richer in polyphenols and flavonoids than the aqueous fraction. The extracts exhibited greater antioxidant capacity against ABTS compared to DPPH and FRAP assays. Antimicrobial activity was assessed by determining MIC\n                    <jats:sub>50%<\/jats:sub>\n                    , MIC\n                    <jats:sub>90%<\/jats:sub>\n                    , and MBC using a technique that correlates the colorimetric method with absorbance and concentration. The results showed that the extracts strongly inhibited all tested microorganisms, with MIC\n                    <jats:sub>50%<\/jats:sub>\n                    , MIC\n                    <jats:sub>90%<\/jats:sub>\n                    , and MBC values ranging from 0.0029 to 4.485\u00a0mg\/mL, 0.0054 to 8.693\u00a0mg\/mL, and 0.006 to 9.659\u00a0mg\/mL, respectively. Furthermore, the extracts demonstrated notable efficacy comparable to antibiotics, especially against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    . These in vitro findings were supported by computational analyses. These methods provide predictive evidence regarding the plausibility of the observed biological effects of the extracts. The results of this research suggest that these Algerian plants exhibit significant therapeutic potential and should be considered for nutritional and medicinal applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71807","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:28:53Z","timestamp":1791613733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UHPLC\/MS\u2010MS Profiling, Antioxidant and Antimicrobial Properties of\n                    <i>Atriplex halimus<\/i>\n                    L. and\n                    <i>Marrubium deserti<\/i>\n                    De No\u00e9 Extracts: In Vitro and In Silico"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9251-0472","authenticated-orcid":false,"given":"Nacira","family":"Siad","sequence":"first","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2324-6153","authenticated-orcid":false,"given":"Chahrazed","family":"Hamia","sequence":"additional","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-118X","authenticated-orcid":false,"given":"Amar","family":"Djeridane","sequence":"additional","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Benalia","sequence":"additional","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reguia","family":"Mahfoudi","sequence":"additional","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"},{"name":"Laboratory of Applied Sciences and Didactic Higher Normal School  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Bouakkaz","sequence":"additional","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Science and Technology Research and Application Center Dicle University  Diyarbakir T\u00fcrkiye"},{"name":"Department of Analytical Chemistry Faculty of Pharmacy Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-2054","authenticated-orcid":false,"given":"Oguz","family":"Cakir","sequence":"additional","affiliation":[{"name":"Science and Technology Research and Application Center Dicle University  Diyarbakir T\u00fcrkiye"},{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3892","authenticated-orcid":false,"given":"Abbas","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Science and Technology Research and Application Center Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-9867","authenticated-orcid":false,"given":"Mohamed","family":"Yousfi","sequence":"additional","affiliation":[{"name":"Laboratoire Des Sciences Fondamentales Amar Telidji University  Laghouat Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nexres.2024.100086"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/B978-0-12-824109-7.00017-0","volume-title":"Phytomedicine","author":"D\u00edaz\u2010Torres R. 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