{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:46:04Z","timestamp":1791791164990,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008844","name":"Liaoning University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2025\u2010DxkjcU45\u201023\u201003"],"award-info":[{"award-number":["2025\u2010DxkjcU45\u201023\u201003"]}],"id":[{"id":"10.13039\/501100008844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008844","name":"Liaoning University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2025\u2010DxkjcU45\u201023\u201024"],"award-info":[{"award-number":["2025\u2010DxkjcU45\u201023\u201024"]}],"id":[{"id":"10.13039\/501100008844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatocellular carcinoma (HCC) lacks effective therapies. Compound Muji Granules (MJ), a traditional Chinese medicine, shows potential anti\u2010HCC activity, but its material basis and synergistic mechanism with exosomal delivery remain unclear. Using UPLC\u2010Q\u2010TOF\u2010MS\/MS, 98 compounds were identified in MJ, including 25 blood\u2010absorbed and 23 tissue\u2010distributed components, with gallic acid (GA) as the core active constituent. hUC\u2010MSC\u2010derived exosomes (hUC\u2010MSCs\u2010Exos) were prepared and combined with MJ or GA. In HepG2 cells and rat HCC organoids, exosome\u2010combined treatment significantly reduced IC50, increased apoptosis and necrosis, and inhibited ATP production. Transcriptomic analysis and qPCR revealed regulation of the IL\u201017\/MAPK\/p53 axis, with downregulation of MEK1\/2, CREB1, and IL17A, and activation of TP53. These findings indicate that MJ exerts anti\u2010HCC efficacy through multi\u2010component synergy, with GA as the main material basis, and hUC\u2010MSCs\u2010Exos enhance these effects by modulating IL\u201017\/MAPK\/p53 signaling, inhibiting tumor proliferation and energy metabolism, and promoting apoptosis.<\/jats:p>","DOI":"10.1002\/cbdv.71809","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:59:07Z","timestamp":1791788347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UPLC\u2010Q\u2010TOF\u2010MS\/MS Profiling and Synergistic Anti\u2010HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC\u2010MSC\u2010Exos"],"prefix":"10.1002","volume":"23","author":[{"given":"Qiang","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yige","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6916-4081","authenticated-orcid":false,"given":"Jinnan","family":"Huo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6735-1574","authenticated-orcid":false,"given":"Liying","family":"Han","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6058-2717","authenticated-orcid":false,"given":"Ying","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Acupuncture\u2010Moxibustion and Tuina Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Acupuncture\u2010Moxibustion and Tuina Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-2113","authenticated-orcid":false,"given":"Yongrui","family":"Bao","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Professional Innovation Technology Center for Multidimensional Analysis of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Liaoning Province Modern Chinese Medicine Research Engineering Laboratory  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-5199","authenticated-orcid":false,"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Professional Innovation Technology Center for Multidimensional Analysis of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Liaoning Province Modern Chinese Medicine Research Engineering Laboratory  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Professional Innovation Technology Center for Multidimensional Analysis of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Liaoning Province Modern Chinese Medicine Research Engineering Laboratory  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-590X","authenticated-orcid":false,"given":"Jiapeng","family":"Leng","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-4615","authenticated-orcid":false,"given":"Xiansheng","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Professional Innovation Technology Center for Multidimensional Analysis of Traditional Chinese Medicine  Dalian Liaoning China"},{"name":"Liaoning Province Modern Chinese Medicine Research Engineering Laboratory  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.10.031"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i44.16630"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520617666170713151149"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002378\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156244"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14080446"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaf165"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2021.09.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6702"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.580593"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520621666211119085834"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010022\u201003111\u2010y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109098"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154589"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010022\u201001798\u2010x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021337"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115853"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001382\u2010y"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70435"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113704"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117805"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom16020269"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.03.004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010025\u201002469\u20107"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.142831"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3927"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.01.014"},{"issue":"3","key":"e_1_2_11_29_1","first-page":"366","article-title":"[Study on Metabolites of Ferulic Acid and Gallic Acid Compatible With Danggui and Chishao in Rat Plasma and Urine]","volume":"37","author":"Ding W.","year":"2012","journal-title":"Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300822"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.01.001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201488R"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205034"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.999935"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg3358"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204097"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001620\u20103"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101730926"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.645805"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000949\u20104"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031492"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001008"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32802"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13527"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2021.8030"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.119467"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:59:10Z","timestamp":1791788350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cbdv.71809"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71809","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71809"}}