{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:47:02Z","timestamp":1791874022102,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["104.01\u20102023.96"],"award-info":[{"award-number":["104.01\u20102023.96"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three previously undescribed 21\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010hydroxyoleanolic acid glycosides, designated Argymekosides A\u2013C (\n                    <jats:bold>1\u20133<\/jats:bold>\n                    ), together with eight known compounds (\n                    <jats:bold>4\u201311<\/jats:bold>\n                    ), were isolated from the aerial parts of\n                    <jats:italic>Argyreia mekongensis<\/jats:italic>\n                    Gagnep. &amp; Courchet. Their structures were elucidated by comprehensive spectroscopic analyses, including HRESIMS and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, as well as comparison with published data. The absolute configurations of three new compounds were determined by electronic circular dichroism (ECD) calculations. The isolated compounds were evaluated for their cytotoxic activities against HepG2, MCF\u20107, and SK\u2010LU\u20101 human cancer cell lines. Compound\n                    <jats:bold>5<\/jats:bold>\n                    exhibited potent cytotoxicity toward all three cell lines, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.06, 5.70, and 5.79 \u00b5M, respectively. Compound\n                    <jats:bold>4<\/jats:bold>\n                    displayed moderate cytotoxic activity against all tested cell lines (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 26.73\u201335.53 \u00b5M), whereas compound\n                    <jats:bold>6<\/jats:bold>\n                    showed weak activity against HepG2 (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 72.03 \u00b5M) and MCF\u20107 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 91.51 \u00b5M). The remaining compounds were inactive, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values exceeding 100 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71814","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:57:50Z","timestamp":1791871070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Argymekosides A\u2010C, Three Undescribed 21\n                    <i>\u03b1<\/i>\n                    \u2010Hydroxyoleanolic Acid Glycosides From\n                    <i>Argyreia mekongensis<\/i>\n                    and Their Cytotoxic Activity"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-311X","authenticated-orcid":false,"given":"Tran Thi Ngoc","family":"Hanh","sequence":"first","affiliation":[{"name":"Institute of Life Sciences Vietnam Academy of Science and Technology (VAST)  Ho Chi Minh City Vietnam"},{"name":"Faculty of Chemistry Graduate University of Science and Technology, VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7390-608X","authenticated-orcid":false,"given":"Nguyen Huu Toan","family":"Phan","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Vietnam Academy of Science and Technology (VAST)  Ho Chi Minh City Vietnam"},{"name":"Faculty of Chemistry Graduate University of Science and Technology, VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-1320","authenticated-orcid":false,"given":"Nguyen Thi Thu","family":"Hien","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Vietnam Academy of Science and Technology (VAST)  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-5779","authenticated-orcid":false,"given":"Pham","family":"Van Huyen","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Vietnam Academy of Science and Technology (VAST)  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Huu Huong","family":"Duyen","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Vietnam Academy of Science and Technology (VAST)  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Dieu","family":"Thuan","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Vietnam Academy of Science and Technology (VAST)  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Thi Hai","family":"Yen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-3786","authenticated-orcid":false,"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Graduate University of Science and Technology, VAST  Hanoi Vietnam"},{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12705\/662.12"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.22244\/rheedea.2024.34.05.04"},{"key":"e_1_2_10_4_1","first-page":"286","article-title":"Medicinal Uses and Biological Activities of Argyreia speciosa Sweet (Hawaiian Baby Woodrose)\u2010 An Overview","volume":"2","author":"Joseph A.","year":"2011","journal-title":"Indian Journal of Natural Products and Resources"},{"key":"e_1_2_10_5_1","first-page":"1501","article-title":"A Literature Review on Argyreia nervosa (Burm. 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