{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:27Z","timestamp":1791614967357,"version":"4.3.4"},"reference-count":130,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oral diseases such as dental caries, periodontitis, denture\u2010related stomatitis, and oral mucositis are prevalent global health concerns primarily driven by microbial dysbiosis and chronic inflammation. Conventional treatments, including antibiotics and mechanical plaque control, have limitations due to antimicrobial resistance and adverse effects. Polyphenols, a diverse class of bioactive phytochemicals, exhibit promising antimicrobial, anti\u2010inflammatory, and antioxidant properties that can be leveraged for oral health management. This review explores the therapeutic potential of polyphenols in targeting key pathogenic mechanisms associated with oral diseases. Polyphenols exert antimicrobial effects by disrupting bacterial membrane integrity, inhibiting biofilm formation, and interfering with quorum sensing pathways of oral pathogens such as\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    and\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    . Additionally, their anti\u2010inflammatory properties involve modulation of NF\u2010\u03baB signaling, suppression of pro\u2010inflammatory cytokines (IL\u20101\u03b2, TNF\u2010\u03b1, COX\u20102), and attenuation of oxidative stress through upregulation of endogenous antioxidants. Polyphenols also influence oral microbiota composition, promoting a balanced microbial ecosystem that supports oral health. However, challenges such as poor bioavailability, stability, and interindividual variability in response remain major hurdles. Advances in nanotechnology and controlled\u2010release systems offer promising strategies to enhance polyphenol efficacy in dental applications. Further research is needed to optimize their formulation, delivery, and clinical validation to establish evidence\u2010based polyphenol\u2010based interventions in dentistry.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71818","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:16:58Z","timestamp":1791613018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2175-4351","authenticated-orcid":false,"given":"Deepa","family":"Subramanian","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Vinayaka Missions Sankarachariyar Dental College, Vinayaka Missions Research Foundation (Deemed to be University) Salem Tamil Nadu India"},{"name":"Department of Prosthodontics RVS Dental College &amp; Hospital  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-0860","authenticated-orcid":false,"given":"Divya","family":"Krishnamoorthi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Vinayaka Missions Sankarachariyar Dental College, Vinayaka Missions Research Foundation (Deemed to be University) Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0194-9820","authenticated-orcid":false,"given":"Gowtham","family":"Kannan","sequence":"additional","affiliation":[{"name":"Centre for Laboratory Animal Technology and Research Sathyabama University Research Park Sathyabama Institute of Science and Technology  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8780-0533","authenticated-orcid":false,"given":"Benedict Mathews","family":"Paul","sequence":"additional","affiliation":[{"name":"Bioprospecting Laboratory, Department of Botany Bharathiar University  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.18759692"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph22040624"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095142"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.17784063"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578\u00d7261425478"},{"key":"e_1_2_17_7_1","volume-title":"Medicinal Plants \u2010 Phytochemical Content and Bioactivity","author":"\u021aigmeanu C. 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