{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:54:44Z","timestamp":1792065284877,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Caudatin (\n                    <jats:bold>1<\/jats:bold>\n                    ) represents one of major C\n                    <jats:sub>21<\/jats:sub>\n                    \u2010steroids isolated from\n                    <jats:italic>Cynanchum otophyllum<\/jats:italic>\n                    . Thirty\u2010one novel caudatin derivatives with arylacryloyl (\n                    <jats:bold>1a\u20131w<\/jats:bold>\n                    ) and quinolyl (\n                    <jats:bold>2a\u20132h<\/jats:bold>\n                    ) substituents were synthesized and structurally characterized by spectroscopic analysis. Their anticancer activities were evaluated against four human cancer cell lines (MCF\u20107, H1299, HeLa, and HepG2). Most compounds exhibit significant antiproliferative effects, among which\n                    <jats:bold>1b<\/jats:bold>\n                    and\n                    <jats:bold>2h<\/jats:bold>\n                    demonstrated broad\u2010spectrum activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 8.54\u201312.12 and 11.43\u201314.25\u00a0uM, respectively. Further mechanistic studies showed that\n                    <jats:bold>1b<\/jats:bold>\n                    induced marked apoptosis in HepG2 cells and modulated cell cycle distribution, with a higher percentage of cells accumulating in the G0\/G1 phase at increased concentrations. Overall, these findings indicate that caudatin derivatives bearing arylacryloyl and quinolyl moieties constitute a preliminary chemical framework for the development of antitumor candidates for caudatin\u2010like natural products.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71821","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:16:36Z","timestamp":1792062996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Synthesis of Novel Caudatin Derivatives Containing Arylacryloyl and Quinolyl Substituents With Anticancer Activity"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-5968","authenticated-orcid":false,"given":"Xiao\u2010San","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u2010Hui","family":"Zhan","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang PR China"},{"name":"Guangdong (Zhanjiang) Provincial Laboratory of Southern Marine Science and Engineering  Zhanjiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang PR China"},{"name":"School of Pharmacy Guangdong Medical University  Dongguan PR 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