{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:41:04Z","timestamp":1792568464173,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273819"],"award-info":[{"award-number":["82273819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four previously undescribed Euphane triterpenes, comprising three dynamic epimerization pairs (\n                    <jats:bold>1\u20133<\/jats:bold>\n                    ) and a tetranor derivative (\n                    <jats:bold>5<\/jats:bold>\n                    ), as well as eight known analogues (\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    \u2013\n                    <jats:bold>12<\/jats:bold>\n                    ), have been separated from the tubers of\n                    <jats:italic>Euphorbia antiquorum<\/jats:italic>\n                    . Their structures were characterized by spectroscopic methods, including HR\u2013ESIMS, NMR and ECD. All of them were evaluated for their inhibitory activity against the diabetic target\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase. Compound\n                    <jats:bold>5<\/jats:bold>\n                    exhibited the most potent activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 13.6\u00a0\u00b5M. The binding mode of\n                    <jats:bold>5<\/jats:bold>\n                    to\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase was further investigated, which identified it as a mixed\u2010type inhibitor.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71823","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:06:11Z","timestamp":1792566371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triterpenes with\n                    <i>\u03b1<\/i>\n                    \u2010Glucosidase Inhibitory Activity from\n                    <i>Euphorbia antiquorum<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6647-6886","authenticated-orcid":false,"given":"Ren\u2010Fen","family":"Ma","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering University of Jinan  Jinan China"},{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8668-3782","authenticated-orcid":false,"given":"Chen\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5959-6473","authenticated-orcid":false,"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00339\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003639.pub2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673272908231115101520"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113895575453806260406053735"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.31621"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010021\u201000690\u20100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1672660"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886315666201217100445"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010021\u201009773\u20101"},{"key":"e_1_2_9_11_1","first-page":"288","volume-title":"Flora of China","author":"Flora of China Editorial Committee","year":"2008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400331"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082257"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103237"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106350"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114233"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00134"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14030469"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25174019"},{"key":"e_1_2_9_20_1","first-page":"287","article-title":"Antiinflammatory and Anti\u2010Arthritic Potential of Aqueous and Alcoholic Extracts of Euphorbia antiquorum Linn","volume":"2","author":"Harpalani A. 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