{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:45:02Z","timestamp":1791873902641,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Plant\u2010derived exosome\u2010like nanoparticles (PELNs) are attracting increasing interest in biomedical research due to their natural origin and components. In this study, PELNs were isolated from\n                    <jats:italic>Rhus coriaria<\/jats:italic>\n                    and physicochemical properties and in vitro biological activities were evaluated. The isolated PELNs were characterised using FE\u2010SEM, nanoparticle\u2010tracking\u2010analysis (NTA) and flow cytometry; chemical composition was analysed by GC\u2013MS. Biological effects were evaluated in A549, HepG2, MCF\u20107 and PC\u20103 tumour cells and normal human fibroblasts (hFib) in terms of proliferation, apoptosis and intracellular reactive oxygen species (ROS). The IC\n                    <jats:sub>50<\/jats:sub>\n                    values for PELNs were determined to be 55.96, 50.0, 26.0 and 49.0\u00a0\u00b5g protein equivalent\/mL in A549, HepG2, MCF\u20107 and PC\u20103 cells, respectively, while in hFib cells, the value was 181.5\u00a0\u00b5g protein equivalent\/mL. This difference indicated that PELNs exerted a greater cytotoxic effect on tumour cells than on normal fibroblasts. PELN treatment altered apoptosis and intracellular ROS levels in tumour cells in a cell line\u2010dependent manner. GC\u2013MS analysis identified tetradecanoic acid, 9\u2010hexadecenoic acid, 9\u2010octadecenoic acid and 9\u2010octadecenamide as the major components. The findings suggest a relationship worth investigating between the chemical composition of PELNs from\n                    <jats:italic>R. coriaria<\/jats:italic>\n                    and their cellular bioactivity and that their selective anti\u2010cancer potential should be examined through further mechanistic studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71833","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:50:17Z","timestamp":1791870617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physicochemical Characterisation and In Vitro Bioactivity of Sumac (\n                    <i>Rhus coriaria<\/i>\n                    )\u2010Derived Exosome\u2010Like Nanoparticles"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-5071","authenticated-orcid":false,"given":"Dilek","family":"BAHAR","sequence":"first","affiliation":[{"name":"Stem Cell Department Genome and Stem Cell Centre (GENKOK) Erciyes University  Kayseri Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.159"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S420748"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.03.017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.05.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010011\u20100689\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010021\u201001491\u20100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.64"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo02295j"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.24323\/akademik\u2010gida.850939"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800832r"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010018\u20100408\u20106"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25993"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.08.017"},{"key":"e_1_2_11_17_1","first-page":"233","article-title":"Cytotoxicity and Antiangiogenic Effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk Oleoresin Methanol Extracts","volume":"10","author":"Mirian M.","year":"2015","journal-title":"Research in Pharmaceutical Sciences"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1049\/iet\u2010nbt.2017.0080"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20204384"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010073"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.12816\/0008245","article-title":"Phytochemistry, Pharmacological Properties and Industrial Applications of Rhus Coriaria L. (sumac)","volume":"7","author":"Abu\u2010Reidah I. M.","year":"2014","journal-title":"Jordan Journal of Biological Sciences"},{"key":"e_1_2_11_23_1","first-page":"559","article-title":"Phytochemical Analysis and in Vitro Antifungal Activities of Bioactive Fractions From Leaves of Rhus coriaria (SUMAC)","volume":"9","author":"Gabr S. A.","year":"2015","journal-title":"Journal of Pure and Applied Microbiology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5861537"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s11694-019-00077-9","article-title":"Measurement of Anticancer, Antidiabetic and Anticholinergic Properties of sumac (Rhus coriaria): Analysis of Its Phenolic Compounds by LC\u2013MS\/MS","volume":"13","author":"Tohma H.","year":"2019","journal-title":"Journal of Food Measurement and Characterisation"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201093876\u20104"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266044"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.08.016"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201011842\u20105"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199\u2010019\u201000253\u20108"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.15671\/hjbc.1356655"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.21448\/ijsm.1335924"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:50:19Z","timestamp":1791870619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cbdv.71833"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71833","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71833"}}