{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:44:36Z","timestamp":1791873876680,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three new limonoids, azadiraindins H\u2010J (\n                    <jats:bold>1\u20133<\/jats:bold>\n                    ), together with three known analogues, were isolated from the leaves of\n                    <jats:italic>Azadirachta indica<\/jats:italic>\n                    . The structures of these compounds were elucidated by comprehensive spectroscopic analysis, including IR, MS, HR\u2010ESI\u2010MS, 1D NMR, and 2D NMR. In addition, all compounds exhibited cytotoxic activities in vitro against HL\u201060, A\u2010549, MCF\u20107, and SW480 cell lines, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 7.51 to 21.97\u00a0\u00b5M. Notably, compound\n                    <jats:bold>2<\/jats:bold>\n                    demonstrated significant cytotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71835","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:46:44Z","timestamp":1791870404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxicity and \u03b1\u2010Amylase Inhibitory Activities of Limonoids From the Leaves of\n                    <i>Azadirachta indica<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5256-4062","authenticated-orcid":false,"given":"Yu\u2010Xin","family":"Yan","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hua","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences  Kunming Yunnan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1021\/cr9004023","article-title":"Meliaceous Limonoids: Chemistry and Biological Activities","volume":"111","author":"Tan Q. G.","year":"2011","journal-title":"Chemical Reviews"},{"issue":"1","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/10286020.2014.962523","article-title":"Three new limonoids From Azadirachta indica","volume":"17","author":"Yan Y. 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