{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:26Z","timestamp":1792586726574,"version":"4.5.0"},"reference-count":114,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The genus\n                    <jats:italic>Heracleum<\/jats:italic>\n                    belongs to the Apiaceae family and is widely distributed across the Northern Hemisphere, predominantly in Eurasia, with approximately 70 species recorded globally. This genus possesses abundant medicinal resources and has a long history of use in traditional medicine, commonly employed to treat various conditions such as inflammation, gastrointestinal bloating, and stomach pain. In recent years, researchers worldwide have isolated and identified numerous chemical constituents from this genus, with coumarin derivatives emerging as the primary bioactive compounds. These exhibit diverse pharmacological activities, including anti\u2010inflammatory, antitumor, hypoglycemic, hepatoprotective, neuroprotective, and antioxidant effects. Moreover, the novel and complex coumarin oligomers (dimers to tetramers) such as canditririn A (trimer) and canditetrarin B (tetramer) with unique cage\u2010like structures present in these plants hold significant promise for medicinal development. This review systematically summarizes the botanical characteristics, chemical constituents, pharmacological activities, and applications of\n                    <jats:italic>Heracleum<\/jats:italic>\n                    species, aiming to provide references for further exploration of their therapeutic value and research development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71836","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:18:13Z","timestamp":1792585093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Botanical, Phytochemistry, Pharmacology and Applications of Genus\n                    <i>Heracleum<\/i>\n                    : A Review"],"prefix":"10.1002","volume":"23","author":[{"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Xi' an Institute for Food and Drug Control  Xi' an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Xi' an Institute for Food and Drug Control  Xi' an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Xi' an Institute for Food and Drug Control  Xi' an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6279-5869","authenticated-orcid":false,"given":"Ye\u2010Zi","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine Shaanxi Key Laboratory of Research and Application of \u201cTaibai Qi Yao  Xianyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao\u2010Miao","family":"Xu","sequence":"additional","affiliation":[{"name":"Xi' an Institute for Food and Drug Control  Xi' an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-1261","authenticated-orcid":false,"given":"Dong\u2010Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine Shaanxi Key Laboratory of Research and Application of \u201cTaibai Qi Yao  Xianyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"21","article-title":"Advances in the Study of Systematics of \u201cEast\u2010Asia Clade\u201d in Apiaceae","volume":"41","author":"Zhou J.","year":"2021","journal-title":"Guihaia"},{"key":"e_1_2_13_3_1","volume-title":"Flora of China","author":"Chinese Academy of Sciences","year":"1992"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00606\u2010007\u20100619\u2010x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1366\u20109516.2006.00305.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12222"},{"key":"e_1_2_13_7_1","first-page":"14","article-title":"Coumarin Compounds of Genus Heracleum L. and Their Bioactivity: A Review","volume":"29","author":"Pan Y.","year":"2023","journal-title":"Chinese Agricultural Science Bulletin"},{"key":"e_1_2_13_8_1","first-page":"63","article-title":"Anatomical Studies on Medicinal Part of Heracleum","volume":"25","author":"Zhao Y.","year":"2004","journal-title":"Journal of China West Normal University(Natural Sciences)"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.07.065"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700184"},{"key":"e_1_2_13_11_1","first-page":"1105","article-title":"Chemical Constituents From Heracleum scabridum","volume":"40","author":"Wei C. 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