{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:47:12Z","timestamp":1791791232586,"version":"4.3.4"},"reference-count":85,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Salvia rosmarinus<\/jats:italic>\n                    , formerly known as\n                    <jats:italic>Rosmarinus officinalis<\/jats:italic>\n                    , is a medicinal plant known as one of the sources of abietane\u2010type diterpenoids. The largest family of chemical constituents from the\n                    <jats:italic>Salvia<\/jats:italic>\n                    genus is abietanes and rearranged abietanes. Since 1976, 365 of the 545 known diterpenoids have been recognized as abietane diterpenoids. Carnosic acid, carnosol, rosmanol, epirosmanol, and their derivatives are among the bioactive abietanes that have gained much attention because of the wide spectrum of pharmacological activities. This review presents information on the distribution, isolation, biosynthesis, structural variation, degradation, semi\u2010synthetic strategies, pharmacokinetics, and bioactivities of abietane\u2010type diterpenoids from\n                    <jats:italic>S. rosmarinus<\/jats:italic>\n                    . Recent developments in eco\u2010friendly extraction techniques, namely, supercritical fluid extraction, microwave\u2010assisted extraction, ultrasound\u2010assisted extraction, and pressurized liquid extraction, are also described in this review. The biosynthetic pathway from geranylgeranyl diphosphate to main diterpenoids, such as carnosic acid and carnosol, is also presented. Moreover, newly isolated compounds, structure\u2010activity relationships, and antioxidant, antimicrobial, anti\u2010inflammatory, neuroprotective, and anticancer activities are included. Moreover, the pharmacokinetics of abietane diterpenoids isolated from\n                    <jats:italic>S. rosmarinus<\/jats:italic>\n                    and their medicinal applications are also covered in this review.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71841","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:07:41Z","timestamp":1791788861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane\u2010Type Diterpenoids From\n                    <i>Salvia rosmarinus<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Rida","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Phytochemistry Division CSIR\u2010 Central Institute of Medicinal and Aromatic Plants  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Singh","sequence":"additional","affiliation":[{"name":"Phytochemistry Division CSIR\u2010 Central Institute of Medicinal and Aromatic Plants  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-9720","authenticated-orcid":false,"given":"Kapil","family":"Dev","sequence":"additional","affiliation":[{"name":"Phytochemistry Division CSIR\u2010 Central Institute of Medicinal and Aromatic Plants  Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_22_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.11.008"},{"key":"e_1_2_22_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2016.12.041"},{"key":"e_1_2_22_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4np00110a"},{"key":"e_1_2_22_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2015.01.058"},{"key":"e_1_2_22_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.105866"},{"key":"e_1_2_22_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200058f"},{"key":"e_1_2_22_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2015.07.015"},{"key":"e_1_2_22_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002179900108"},{"key":"e_1_2_22_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300052"},{"key":"e_1_2_22_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130\u2010011\u20100233\u20105"},{"key":"e_1_2_22_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.11.001"},{"issue":"1","key":"e_1_2_22_13_1","first-page":"19","article-title":"Exploring the Therapeutic Potential of Rosemary: An In\u2010Depth Review of Its Pharmacological Properties","volume":"6","author":"Teja Y. 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