{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:55:18Z","timestamp":1792065318892,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["3401376"],"award-info":[{"award-number":["3401376"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The soft coral\n                    <jats:italic>Sarcophyton tenuispiculatum<\/jats:italic>\n                    was investigated for its secondary metabolites, leading to the isolation of four natural isolates, including 7\u03b1,8\u03b1\u2010epoxy\u20101(15),3,11\u2010cembratriene\u201016,2\u03b2\u2010olide (\n                    <jats:bold>1<\/jats:bold>\n                    ), 2\u03b2,16,7\u03b1,8\u03b1\u2010diEpoxy\u20101(15),3,11\u2010cembratriene (\n                    <jats:bold>2<\/jats:bold>\n                    ), apo\u20109\u2032\u2010fucoxanthinone (\n                    <jats:bold>3<\/jats:bold>\n                    ), and (+)\u2010viridiflorol (\n                    <jats:bold>4<\/jats:bold>\n                    ). Semi\u2010synthetic modification of compound\n                    <jats:bold>1<\/jats:bold>\n                    produced five new cembranoids: epi\u2010Trochelioid B (\n                    <jats:bold>5<\/jats:bold>\n                    ), chlorobenzocembrin (\n                    <jats:bold>6<\/jats:bold>\n                    ), benzocembrin (\n                    <jats:bold>7<\/jats:bold>\n                    ), nitrobenzocembrin (\n                    <jats:bold>8<\/jats:bold>\n                    ), and Trochelioid C (\n                    <jats:bold>9<\/jats:bold>\n                    ). Structural elucidation was achieved using extensive spectroscopic analyses, including 1D\/2D NMR and HR\u2010ESI\u2010MS. Biological evaluation demonstrated that chlorobenzocembrin (\n                    <jats:bold>6<\/jats:bold>\n                    ) exhibited more cytotoxic activity against breast cancer cell lines MCF\u20107 and MDA\u2010MB\u2010231, inducing apoptosis through ROS accumulation and caspase\u20106 activation. Acute toxicity studies in mice revealed hepatotoxicity and nephrotoxicity in doses &gt; 250\u00a0mg\/kg. Preliminary antiproliferative SAR highlights that epoxide ring opening followed by aryl substitution at C\u20117 on 7\u03b1,8\u03b1\u2010epoxy\u20101(15),3,11\u2010cembratriene\u201016,2\u03b2\u2010olide enhanced cytotoxic activity and suggests that incorporating substituents associated with enhanced cytotoxic activity at the same position may represent a promising strategy for semi\u2011synthetic optimization of cembranoid scaffolds toward more potent and selective anticancer agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71842","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:22:15Z","timestamp":1792063335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Cembranoid Diterpenes From\n                    <i>Sarcophyton tenuispiculatum<\/i>\n                    and Semi\u2011Synthetic Derivatives with Pro\u2011Apoptotic Activity in Breast Cancer Cells"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0830-4901","authenticated-orcid":false,"given":"Samin","family":"Mousavi","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Yegdaneh","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Aghaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-4734","authenticated-orcid":false,"given":"Mustafa","family":"Ghanadian","sequence":"additional","affiliation":[{"name":"Isfahan Pharmaceutical Sciences Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114165"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11093186"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11104083"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19010008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0497393"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.06.060"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041\u20100101(74)90192\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104020(01)97451\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50121a020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.03.034"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20102670(01)01307\u20101"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2013.05.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20101981\u201029414"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00304948.2021.1979357"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113411"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29141"},{"issue":"5","key":"e_1_2_10_18_1","first-page":"1474","article-title":"Deficiency of Caspase\u20103 in MCF7 Cells Blocks Bax\u2010mediated Nuclear Fragmentation but Not Cell Death","volume":"7","author":"Kagawa S.","year":"2001","journal-title":"Clinical cancer research"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735\u20105362.220963"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104636"}],"container-title":["Chemistry &amp; 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