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Leaf essential oils of\n                    <jats:italic>Psidium guajava<\/jats:italic>\n                    L. were obtained by hydrodistillation from fresh or previously frozen leaves fragmented manually or mechanically, and assessed for GC\u2010MS composition, cytotoxicity and biological activities. Fresh leaves ground in a mixer (EOFH\u2010M) gave a sesquiterpene\u2010rich profile dominated by \u03b2\u2010caryophyllene and \u03b1\u2010humulene, along with the best cell\u2010viability profile in L929 fibroblasts and BALB\/c macrophages. EOFH\u2010M reduced nitric oxide and intracellular reactive oxygen species and showed a fungicidal effect against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and the emerging and resistant microorganism\n                    <jats:italic>Candida auris<\/jats:italic>\n                    , whereas isolated \u03b2\u2010caryophyllene was fungistatic. Leaf pre\u2010processing therefore substantially influences the composition, safety and antifungal potential of\n                    <jats:italic>P. guajava<\/jats:italic>\n                    essential oil.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71843","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:27:17Z","timestamp":1792063637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Plant Pre\u2010Processing on the Chemical Profile of\n                    <i>Psidium guajava<\/i>\n                    L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1062-8407","authenticated-orcid":false,"given":"Tarsila da C.","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Federal Fluminense University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari S\u00e9rgio de O.","family":"Lemos","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Federal Fluminense University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Juan S.","family":"Fortes","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences Federal University of Juiz de Fora (UFJF) Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-1608","authenticated-orcid":false,"given":"D\u00e9bora N.","family":"Eiriz","sequence":"additional","affiliation":[{"name":"Analytical Separations and Chemometrics Research Group Federal Fluminense University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-278X","authenticated-orcid":false,"given":"Elaine S.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Microbiology, and Immunology, Institute of Biological Sciences Federal University of Juiz de Fora (UFJF) Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-8189","authenticated-orcid":false,"given":"Lucas de A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences Federal University of Juiz de Fora (UFJF) Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-8056","authenticated-orcid":false,"given":"Luciana M.","family":"Chedier","sequence":"additional","affiliation":[{"name":"Department of Botany, Institute of Biological Sciences Federal University of Juiz de Fora (UFJF) Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-3513","authenticated-orcid":false,"given":"Lucas M.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Analytical Separations and Chemometrics Research Group Federal Fluminense University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1481-2859","authenticated-orcid":false,"given":"N\u00fabia B.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences Federal University of Juiz de Fora (UFJF) Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-2277","authenticated-orcid":false,"given":"Rodrigo L.","family":"Fabri","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences Federal University of Juiz de Fora (UFJF) Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8295-7011","authenticated-orcid":false,"given":"Selma R. de","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of General Biology, Institute of Biology Federal Fluminense University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-1051","authenticated-orcid":false,"given":"Alessandra L.","family":"Valverde","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Federal Fluminense University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.04.025"},{"key":"e_1_2_11_3_1","article-title":"Review of Phytochemicals Present in Psidium guajava Plant and Its Mechanism of Action on Medicinal Activities","volume":"15","author":"Joshi D. 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