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The growing resistance to antimalarial drugs underscores the urgent need for the development of new therapeutic agents. This study describes the semisynthesis of eight new 1,4\u2010disubstituted 1,2,3\u2010triazole derivatives (\n                    <jats:bold>3\u201310<\/jats:bold>\n                    ) from\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010dimethyltryptamine (\n                    <jats:bold>1<\/jats:bold>\n                    ), isolated from\n                    <jats:italic>Mimosa tenuiflora<\/jats:italic>\n                    . The derivatives were obtained through copper(I)\u2010catalyzed alkyne\u2013azide cycloaddition (CuAAC) reactions and characterized by NMR and mass spectrometry. Compound\n                    <jats:bold>1<\/jats:bold>\n                    showed low in vitro activity against the W2 strain of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0288.4\u00a0\u00b1\u00a028.53\u00a0\u00b5M), whereas compound\n                    <jats:bold>4<\/jats:bold>\n                    demonstrated promising activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a04.8\u00a0\u00b1\u00a00.32\u00a0\u00b5M), with higher selectivity toward the TOV\u201021G cell line. In in silico studies, all derivatives showed more favorable binding energy values compared to compound\n                    <jats:bold>1<\/jats:bold>\n                    , particularly compound\n                    <jats:bold>7<\/jats:bold>\n                    (\u22129.8\u00a0kcal\/mol) relative to the crystallographic ligand (\u22126.9\u00a0kcal\/mol). These results highlight the importance of structural modifications in the development of new antimalarial agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71849","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:03:03Z","timestamp":1792584183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of 1,2,3\u2010Triazole Derivatives of\n                    <i>N<\/i>\n                    ,\n                    <i>N<\/i>\n                    \u2010Dimethyltryptamine Isolated From\n                    <i>Mimosa tenuiflora<\/i>\n                    Root Bark: Antiplasmodial Activity In Silico and In Vitro"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8217-3655","authenticated-orcid":false,"given":"Renato Pinto","family":"de Sousa","sequence":"first","affiliation":[{"name":"Department of Chemistry Federal University of 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