{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:40:12Z","timestamp":1792568412328,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ferula oopoda<\/jats:italic>\n                    (Boiss. and Buhse) Boiss. is an ethnomedicinally important species widely used in Central and South Asia for the treatment of gastrointestinal, respiratory, neurological, and parasitic disorders. Despite its extensive traditional applications, comprehensive scientific evaluation of its pharmacological potential remains limited. This review systematically analyzes, for the first time, the available literature on the botany, phytochemical composition, ethnomedicinal uses, and pharmacological activities of\n                    <jats:italic>F. oopoda<\/jats:italic>\n                    , while highlighting current research gaps and future perspectives for drug discovery. To date, thirty\u2010three secondary metabolites have been isolated from\n                    <jats:italic>F. oopoda<\/jats:italic>\n                    , including sesquiterpene lactones (STLs), sesquiterpenoids, monoterpene\u2010phenyl esters, and phenolic acid glucosides. In addition, gas chromatography mass spectrometry (GC\u2013MS) and liquid chromatography mass spectrometry (LC\u2013MS) analyses detected several low\u2010molecular\u2010weight constituents in essential oils and organic extracts. Both crude extracts and isolated compounds have displayed a broad spectrum of biological activities, including antibacterial, anti\u2010plasmodial, antioxidant, anti\u2010inflammatory, antimutagenic, and antiulcer effects. However, detailed mechanistic studies, pharmacokinetic investigations, and in vivo validations remain limited. Future research integrating structure\u2010activity relationship studies and molecular target identification with omics\u2010based approaches (e.g., metabolomics), in silico techniques such as molecular docking, and nano\u2010drug delivery systems will be essential to advance its development into evidence\u2010based therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71851","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:59:51Z","timestamp":1792565991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Review on\n                    <i>Ferula oopoda<\/i>\n                    (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5038-7010","authenticated-orcid":false,"given":"Muhammad","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setya Widi Ayuning","family":"Permanasari","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Department of Aquatic Resources Management Faculty of Fisheries and Marine Sciences Brawijaya University  Jl. Veteran Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-6887","authenticated-orcid":false,"given":"Shah Iram","family":"Niaz","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences Gomal University  Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-8978","authenticated-orcid":false,"given":"Aizhamal","family":"Baiseitova","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology Al\u2010Farabi Kazakh National University  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-7556","authenticated-orcid":false,"given":"Abdul Bari","family":"Shah","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology Al\u2010Farabi Kazakh National University  Almaty Kazakhstan"},{"name":"School of Chemical Engineering Kazakh\u2010British Technical University  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-1320","authenticated-orcid":false,"given":"Yuan Bin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants9060740"},{"key":"e_1_2_14_3_1","first-page":"15","article-title":"Distribution and Taxonomy of Ferula L.: A Review","volume":"5","author":"Yaqoob U.","year":"2016","journal-title":"Research & Reviews: Journal of Botany"},{"key":"e_1_2_14_4_1","volume-title":"A Dictionary of Iranian Plant Names: Latin, English, Persian","author":"Mozaffarian V.","year":"1996"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.12.012"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2004.10.009"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03746609109468059"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28083579"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2011.10643937"},{"key":"e_1_2_14_10_1","first-page":"109","article-title":"Ethnobotany, Ethnopharmacology and Drug Discovery","volume":"2","author":"Ghorbani A.","year":"2006","journal-title":"Iranian Journal of Pharmaceutical Sciences"},{"key":"e_1_2_14_11_1","first-page":"19","article-title":"Study the Ethnobotany of Medicinal Plants in Sirjan, Kerman Province","volume":"1","author":"Sharififar F.","year":"2010","journal-title":"Iranian Journal of Medicinal Herbs"},{"key":"e_1_2_14_12_1","unstructured":"S.Ahmed \u201cIsolation and Structural Elucidation of Chemical Constituents From Fumaria Indica Ferula oopodaand Withania Somnifera \u201d (University of Karachi 1998)."},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201000148"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2018.03.012"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.22092\/ijb.2024.367358.1496"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/botlinnean\/boy055"},{"key":"e_1_2_14_17_1","unstructured":"RESNA Wildlife Ferula oopoda\u2014Apiaceae (Isfahan University of Technology 2025) https:\/\/resna.iut.ac.ir\/wildlife\/mouteh\/ferula\u2010oopoda\u2010apiaceae."},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(97)00123\u20102"},{"key":"e_1_2_14_19_1","first-page":"621","article-title":"Ethnobotanical Knowledge of Apiaceae family in Iran: A Review","volume":"6","author":"Amiri M. 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