{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:42:36Z","timestamp":1792586556570,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The enzyme inhibitory and antioxidant activities of eight medicinal plants from T\u00fcrkiye were investigated in vitro. Extracts were evaluated for their inhibitory effects on\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase, pancreatic lipase, and pancreatic cholesterol esterase, together with antioxidant properties using DPPH radical scavenging, metal chelation, and ferric\u2010reducing power assays. Among the tested samples,\n                    <jats:italic>Morus nigra<\/jats:italic>\n                    extract exhibited the strongest\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 43.34 \u00b1 1.76 \u00b5g\/mL) and showed moderate activity against pancreatic lipase and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase. LC\u2010MS\/MS analysis of the 80% ethanol extract of\n                    <jats:italic>M. nigra<\/jats:italic>\n                    led to the identification of 22 phenolic compounds, with quinic acid as the major compound, followed by isoquercitrin and chlorogenic acid. The observed bioactivities may be attributed to the combined effects of these phenolic compounds. These findings suggest that\n                    <jats:italic>M. nigra<\/jats:italic>\n                    may serve as a promising natural source of phenolic compounds with potential inhibitory activity against enzymes associated with metabolic disorders.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71852","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:00:01Z","timestamp":1792584001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Enzyme Inhibitory and Antioxidant Activities of Selected Turkish Medicinal Plants With LC\u2010MS\/MS Profiling of\n                    <i>Morus nigra<\/i>\n                    Extract"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-9832","authenticated-orcid":false,"given":"Sultan","family":"Pekacar","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-9860","authenticated-orcid":false,"given":"Bur\u00e7in","family":"\u00d6z\u00fcpek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-0221","authenticated-orcid":false,"given":"Semih","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy S\u00fcleyman Demirel University  Isparta T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Research and Application Center  Diyarbak\u0131r T\u00fcrkiye"},{"name":"Department of Analytical Chemistry Faculty of Pharmacy Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-2054","authenticated-orcid":false,"given":"O\u011fuz","family":"\u00c7akir","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Research and Application Center  Diyarbak\u0131r T\u00fcrkiye"},{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3892","authenticated-orcid":false,"given":"Abbas","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Research and Application Center  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Tugay","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-4048","authenticated-orcid":false,"given":"Didem","family":"Deliorman Orhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"41","article-title":"Diyabetle M\u00fccadelede Diyabet Risklerinin Belirlenmesi Ve Tan\u0131lama","volume":"2","author":"Yal\u0131n H.","year":"2011","journal-title":"Journal of Turkish Family Physician"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.12.012"},{"key":"e_1_2_9_4_1","first-page":"7","article-title":"Diyabette Oksidatif Stres Ve Antioksidanlar\u0131n Rol\u00fc","volume":"1","author":"Hamamcio\u011flu A. 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