{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:40:43Z","timestamp":1792586443434,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This work reports the design and development of two series of imine\u2010linked imidazo[1,2\u2010\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrimidine\u2010thiazole\/1,3,4\u2010thiadiazole derivatives using a molecular hybridization approach as anti\u2010tubercular agents. A total of thirty\u2010seven new hybrid compounds (B1\u2010B37) were synthesized and characterized. One final molecule, B20, was structurally confirmed by single\u2010crystal x\u2010ray diffraction analysis. All the final compounds (B1\u2010B37) were tested for activity against the\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    H37Rv strain. Compounds B5, B26, and B30 exhibited significant inhibitory effects, with MICs of 12.5, 12.5, and 6.25\u00a0\u00b5g\/mL, respectively. All novel final compounds also displayed effective antibacterial action against four bacterial strains\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>E. coli<\/jats:italic>\n                    ,\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    , and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    . Toxicity tests on mouse fibroblast (L929) cell lines revealed that the highly active anti\u2010TB compounds (B5, B26, and B30) were nontoxic. Furthermore, the outcomes of the in silico ADME evaluation, DFT analysis, molecular docking studies (targeting CYP121 and InhA), and dynamic simulation demonstrated the potent compounds' great potential as prospective scaffolds for the development of novel antitubercular drugs.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71857","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:51:14Z","timestamp":1792583474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Acid Mediated Synthesis of Imidazo[1,2\u2010a]Pyrimidine\u2013Thiazole\/1,3,4\u2010Thiadiazole Hybrids: Design, Characterization and In\u2010Vitro Biological Evaluation"],"prefix":"10.1002","volume":"23","author":[{"given":"Dinesha","family":"P","sequence":"first","affiliation":[{"name":"Organic and Medicinal Chemistry Laboratory Department of Chemistry National Institute of Technology Karnataka  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4312-1717","authenticated-orcid":false,"given":"Shivakumar","family":"Naik","sequence":"additional","affiliation":[{"name":"Organic and Medicinal Chemistry Laboratory Department of Chemistry National Institute of Technology Karnataka  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-878X","authenticated-orcid":false,"given":"Udayakumar","family":"D","sequence":"additional","affiliation":[{"name":"Organic and Medicinal Chemistry Laboratory Department of Chemistry National Institute of Technology Karnataka  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maithilee S.","family":"Dhekale","sequence":"additional","affiliation":[{"name":"Organic and Medicinal Chemistry Laboratory Department of Chemistry National Institute of Technology Karnataka  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7493-9738","authenticated-orcid":false,"given":"Sampat Parayya","family":"Vibhutimath","sequence":"additional","affiliation":[{"name":"Organic and Medicinal Chemistry Laboratory Department of Chemistry National Institute of Technology Karnataka  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-6006","authenticated-orcid":false,"given":"Rajkumar Reddy","family":"Rajula","sequence":"additional","affiliation":[{"name":"School of Sciences Woxsen University  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-2451","authenticated-orcid":false,"given":"Revanasiddappa","family":"B.C","sequence":"additional","affiliation":[{"name":"Nitte (Deemed to Be University) NGSM Institute of Pharmaceutical Sciences (NGSMIPS) Department of Pharmaceutical Chemistry  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2476-3918","authenticated-orcid":false,"given":"Nanditha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Nitte (Deemed to Be University) NGSM Institute of Pharmaceutical Sciences (NGSMIPS) Department of Pharmaceutical Chemistry  Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0308-015X","authenticated-orcid":false,"given":"Naveena S.","family":"Veeranagaiah","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Karnataka  Kalaburagi Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01833"},{"key":"e_1_2_9_3_1","unstructured":"Global Tuberculosis Report 2025 2025."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)60410\u20102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.30574\/wjbphs.2024.17.2.0056","article-title":"Review for QSAR Studies and Drug Design of Selected Heterocyclic Nucleus of Antitubercular Drugs","volume":"17","author":"R R. 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