{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:40:47Z","timestamp":1792586447183,"version":"4.5.0"},"reference-count":111,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite well\u2010documented pharmacological profiles of lignans in human therapeutics, their agricultural and veterinary potential remains fragmented without unified collation. This systematic review synthesizes literature published from 2001 to 2026, categorizing lignan compounds by carbon\u2010skeleton classification frameworks. Representative classic lignans, neolignans, oligolignans, and complex lignans exhibit diverse bioactivities, including antifungal, antibacterial, plant\u2010growth\u2010regulating, herbicidal, insecticidal, and acaricidal properties. We compiled quantitative bioassay metrics including half\u2010maximal effective concentration (EC\n                    <jats:sub>50<\/jats:sub>\n                    ), median lethal concentration (LC\n                    <jats:sub>50<\/jats:sub>\n                    ), and minimum inhibitory concentration (MIC), alongside livestock production indices to compare agricultural and veterinary performance. Structure\u2010activity relationships and molecular mechanisms of key lignan scaffolds are analyzed, and research bottlenecks for each subtype are highlighted. Prospects are outlined for developing lignan\u2010derived green botanical pesticides and natural antibiotic\u2010replacing feed additives. This review delivers systematic data and theoretical reference for further exploitation of lignan\u2010based agrochemical leads and livestock antibiotic alternatives.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71862","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:53:42Z","timestamp":1792583622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Agricultural Applications of Lignans"],"prefix":"10.1002","volume":"23","author":[{"given":"Kaida","family":"Li","sequence":"first","affiliation":[{"name":"Yunnan University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Technology Yunnan University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjie","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource Yunnan University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1684-718X","authenticated-orcid":false,"given":"Feng","family":"Hao","sequence":"additional","affiliation":[{"name":"Yunnan University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wei","sequence":"additional","affiliation":[{"name":"Yunnan University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0970-4920","authenticated-orcid":false,"given":"Le","family":"Cai","sequence":"additional","affiliation":[{"name":"Yunnan University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123251"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9sc02682g"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104284"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113326"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2023.110001"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6np00021e"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106831"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2014.11.044"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114145"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106872"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9sc00446g"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2026.141062"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.137023"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.47278\/journal.ijab\/2024.195"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40538\u2010025\u201000867\u2010y"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aac.2026.06.004"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c01809"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.144228"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.70006"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.70707"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2025.102146"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.04.074"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.70501"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104139"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.12838"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2022.105042"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12298\u2010022\u201001227\u2010y"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212331"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2019.109020"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ery333"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2017.10.012"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00344\u2010011\u20109245\u20105"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf202561p"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c14855"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.05.020"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4015526"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130\u2010025\u201001346\u20103"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzaa050_012"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.47278\/journal.ijab\/2024.100"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.12.021"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/s175173111600207x"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937\u2010015\u20100059\u20103"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2008.07.006"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11746\u2010006\u20105034\u2010x"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.47278\/journal.ijvs\/2025.075"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127191"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093769"},{"key":"e_1_2_17_49_1","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/jf703594z","article-title":"Evaluation of Insecticidal Activity of Diterpenes and Lignans from Aristolochia Malmeana Against Anticarsia gemmatalis","volume":"56","author":"Messiano G. B.","year":"2008","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.70139"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.06.023"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2024.740980"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2018.08.003"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16285"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.02.018"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201004136\u20103"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33062"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b02036"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.07.076"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.10.081"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.10.073"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.08.044"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201100855"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.07.075"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.07.116"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202302595"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c06384"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2026.107152"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765\u2010026\u201001084\u20103"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201093785\u2010w"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.70413"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.3546"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176391"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4046396"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.09.006"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1420"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2023.106625"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.09.128"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4fo05933f"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/are.12833"},{"key":"e_1_2_17_81_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13071-017-2154-0","article-title":"Larvicidal Activity of Lignans and Alkaloid Identified in Zanthoxylum Piperitum Bark toward Insecticide\u2010Susceptible and Wild Culex pipiens Pallens and Aedes aegypti","volume":"10","author":"Kim S.\u2010I.","year":"2017","journal-title":"Parasites & Vectors"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2025.1497732"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2022.2087650"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262836"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113270"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c02682"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2026.107175"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c02331"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c01838"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.08.003"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3908"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c10109"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2023.103378"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.10.047"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010021\u201000611\u20100"},{"key":"e_1_2_17_96_1","doi-asserted-by":"crossref","unstructured":"G.Giovani R. I.Kusuma M. S.Daulai et\u00a0al. \u201cNote: This Article is Currently in Press (Advance Online Publication) inInternational Journal of Veterinary Science \u201d (2025) https:\/\/doi.org\/10.47278\/journal.ijvs\/2025.026.","DOI":"10.47278\/journal.ijvs\/2025.026"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2024.2302825"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2023.0131"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00151"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26030958"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2021.1961920"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.632767"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23789"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010023\u201030182\u20108"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture15101053"},{"key":"e_1_2_17_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18020169"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S290444"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S178416"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105745"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143119"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00487"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133488"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:53:43Z","timestamp":1792583623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":111,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cbdv.71862"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71862","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71862"}}