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In the present study, two new C25 steroids with a 7\/7\/6\/5\u2010tetracyclic scaffold, named (11\n                    <jats:italic>R<\/jats:italic>\n                    ,20\n                    <jats:italic>R<\/jats:italic>\n                    )\u201011\u2010hydroxy\u201024\u2010oxocyclocitrinol (\n                    <jats:bold>1<\/jats:bold>\n                    ) and (11\n                    <jats:italic>R<\/jats:italic>\n                    )\u201011\u2010hydroxy\u2010erythro\u201023\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010methylneocyclocitrinol D (\n                    <jats:bold>2<\/jats:bold>\n                    ), together with nine known analogues (\n                    <jats:bold>3\u201311<\/jats:bold>\n                    ), were isolated and characterized from the marine\u2010derived fungus\n                    <jats:italic>Lodderomyces<\/jats:italic>\n                    sp. Z\u20101, which was obtained from the starfish\n                    <jats:italic>Culcita novaeguineae<\/jats:italic>\n                    collected from the South China Sea. The structures and absolute configurations of new compounds were established through extensive spectroscopic analyses, quantum chemical calculations, and comparison of spectral data with those of related analogues reported in the literature. Additionally, the single\u2010crystal x\u2010ray crystallographic structure of the known compound\n                    <jats:bold>4<\/jats:bold>\n                    is reported here for the first time. In the anti\u2010inflammatory assay, compound\n                    <jats:bold>10<\/jats:bold>\n                    exhibited weak inhibitory activity against LPS\u2010induced NO production in RAW264.7 macrophages with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 41.72 \u00b1 1.81 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71867","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:34:38Z","timestamp":1792654478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two New 7\/7\/6\/5\u2010Tetracyclic C25 Steroids From the Marine\u2010Derived Fungus\n                    <i>Lodderomyces<\/i>\n                    sp. Z\u20101"],"prefix":"10.1002","volume":"23","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei Anhui China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9828-7431","authenticated-orcid":false,"given":"Song\u2010Wei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Min","family":"Pan","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Gong","family":"Yao","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-2070","authenticated-orcid":false,"given":"Yue\u2010Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8805-3963","authenticated-orcid":false,"given":"Ming\u2010Zhi","family":"Su","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei Anhui China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1039\/D5NP00080G","article-title":"Marine Natural Products","volume":"43","author":"Carroll A. 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