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UDCA (40\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.g.) was administered daily from the fifth to the 35th day after the alloxan treatment. The treatment of diabetic rats with UDCA improved the pancreatic morphology disturbed by the alloxan treatment: UDCA increased the number of pancreatic islets and \u03b2\u2010cells, the \u03b2\u2010\/\u03b1\u2010cell ratio and decreased the number of \u03b1\u2010cells. As the morphometric data suggest, the treatment of diabetic animals with UDCA significantly increased the area of \u03b2\u2010cell cytoplasmatic granules stained by paraldehyde\u2013fuchsin. The concentration of blood glucose in diabetic rats was gradually decreased after the UDCA treatment, and at the end of the experiment reached the control value. The treatment with UDCA raised the serum insulin level in diabetic rats about 2.5\u2010fold, but this concentration was significantly lower as compared to the control group. The content of lipid peroxidation end\u2010products, hydroxyalkenals and malondialdehyde, was significantly elevated in the alloxan\u2010treated rats, whereas the treatment with UDCA normalized these parameters. The present data indicate that UDCA acts as an effective antidiabetic agent in alloxan\u2010induced diabetes and its beneficial effects in diabetic rats can be related to the antioxidant properties of UDCA. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1063","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T12:09:28Z","timestamp":1078229368000},"page":"97-103","source":"Crossref","is-referenced-by-count":16,"title":["The protective effect of ursodeoxycholic acid in alloxan\u2010induced 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