{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:47:00Z","timestamp":1768013220174,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T00:00:00Z","timestamp":1087776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study we investigated TNF\u2010\u03b1 and leptin levels in two different liver fibrosis models induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) and common bile duct ligation (CBDL). A total of 36 male rats of Albino\u2010Wistar strain were allocated to three groups. One of the groups was the control. The second group received 0.15\u2009ml\u2009100\u2009g<jats:sup>\u22121<\/jats:sup> CCl<jats:sub>4<\/jats:sub> subcutaneously for 6 weeks, 3 days per week. The third group underwent common bile duct ligation (CBDL) and was monitored for 4 weeks. Histopathological investigation included fibrosis, steatosis and inflammation. Serum IL\u20106 and TNF\u2010\u03b1 levels were analysed by ELISA methods and leptin was analysed by RIA. Fibrosis and steatosis increased significantly in the CCl<jats:sub>4<\/jats:sub> group in comparison with the CBDL group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Leptin and TNF\u2010\u03b1 levels in CCl<jats:sub>4<\/jats:sub> group were higher than those in the CBDL and control groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). TNF\u2010\u03b1 and leptin levels were not related to each another in either the CCl<jats:sub>4<\/jats:sub> group or the CBDL group (<jats:italic>r<\/jats:italic>=0.22, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05; <jats:italic>r<\/jats:italic>=0.19, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The IL\u20106 level was higher in the CCl<jats:sub>4<\/jats:sub> group in relation to severity of inflammation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). TNF\u2010\u03b1 and leptin levels were higher in animals with liver fibrosis induced by CCl<jats:sub>4<\/jats:sub>, than they were in those whose liver fibrosis was induced by common bile duct ligation. Leptin and TNF\u2010\u03b1 may be less effective on the development of liver fibrosis in the group which underwent common bile duct ligation. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1114","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T13:01:49Z","timestamp":1087822909000},"page":"359-363","source":"Crossref","is-referenced-by-count":19,"title":["TNF\u2010\u03b1 and leptin in experimental liver fibrosis models induced by carbon tetrachloride and by common bile duct ligation"],"prefix":"10.1002","volume":"22","author":[{"given":"\u0130brahim 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