{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:16:21Z","timestamp":1775081781376,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T00:00:00Z","timestamp":1087776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peroxisomes, also termed as microbodies, are now known to carry out several specialized metabolic activities that are vital to cellular function. A defect in peroxisomal function leads to development of a fatal human disease, and a number of peroxisomal disorders are now linked to inherited peroxisomal enzyme abnormalities. Peroxisomal enzyme activities are also altered during pathophysiological conditions through various endogenously produced bio\u2010molecules such as nitric oxide (NO). NO produced by cytokines or NO\u2010donors is known to modulate peroxisomal functions, and these effects of NO are mediated through cGMP. We are reporting for the first time that <jats:sc>L<\/jats:sc>\u2010carnitine (1\u20135\u2009mm) prevents cGMP\u2010mediated impairment of peroxisomal enzyme activities. Cyclic GMP (250\u20131000\u2009\u03bc<jats:sc>M<\/jats:sc>) significantly inhibited (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) the specific activities of catalase, acyl CoA oxidase and dihydroxyacetone\u2010phosphate acyltransferase (DHAPATase) in human dermal fibroblasts, and treatment of cells with 1\u20135\u2009m<jats:sc>M<\/jats:sc> of carnitine significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) reduced the inhibitory effects of cGMP on peroxisomal enzyme activities. These findings suggest that carnitine, previously thought to participate only in fatty acid oxidation, may in fact be regulating other cellular events including oxidative stress, and could possibly be used to correct cytokine\u2010impaired peroxisomal functions. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1117","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T13:01:51Z","timestamp":1087822911000},"page":"365-371","source":"Crossref","is-referenced-by-count":3,"title":["Carnitine prevents cyclic GMP\u2010induced inhibition of peroxisomal enzyme activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Gursev S.","family":"Dhaunsi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Al\u2010Essa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar T.","family":"Ozand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allie","family":"Moosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.bi.61.070192.001105","article-title":"Biochemistry of peroxisomes","volume":"61","author":"Van den Bosch H","year":"1992","journal-title":"Ann Rev Biochem"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(93)90072-Z"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0290250"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1993.02160300023015"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90492-F"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb36759.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00926522"},{"key":"e_1_2_1_9_2","first-page":"763","article-title":"Nitric oxide regulates peroxisomal enzyme activities","volume":"33","author":"Kremser K","year":"1995","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715769509147526"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3203"},{"key":"e_1_2_1_12_2","article-title":"Cyclic GMP\u2010mediated modulation of peroxisomal functions by nitric oxide in human dermal fibroblasts","volume":"11","author":"Dhaunsi GS","year":"1997","journal-title":"FASEB J"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0920179"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00711435"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb21415.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00312.x"},{"key":"e_1_2_1_17_2","first-page":"109","article-title":"A rapid and economical method of preparing radioiodinated cyclic nucleotide derivatives for use in radioimmunoassays","volume":"11","author":"Oehlenschlager WF","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310226"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.15.1464372"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(98)00064-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00249.2002"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02905-0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080380313"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00313-3"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2232"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(01)00159-7"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0021-9258(19)85065-2","article-title":"Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells: reduction of Ca2+ by atriopeptin and 8\u2010bromo\u2010cGMP is mediated by cyclic GMP\u2010dependent protein kinase","volume":"264","author":"Cornwell TL","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520100232"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90071-8"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.1117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.1117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:56:53Z","timestamp":1760039813000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.1117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,21]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/cbf.1117"],"URL":"https:\/\/doi.org\/10.1002\/cbf.1117","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,21]]}}}