{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:14:59Z","timestamp":1761128099412,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,17]],"date-time":"2004-09-17T00:00:00Z","timestamp":1095379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropylene mesh is known as an inert material, it is experimentally proven that mesh generates a chronic inflammatory tissue reaction. The aim of the present study was to investigate the long\u2010term effects of polypropylene mesh material used in inguinal hernia operations on testicular function, testicular nitric oxide (NO) metabolism and germ cell\u2010specific apoptosis in rats. The study comprised 40 male rats that were randomly allocated into two groups. In group 1, the left spermatic cord was elevated and a 0.5\u2009\u00d7\u20091\u2009cm polypropylene mesh was placed behind the left inguinal spermatic cord and group 2 consisted of the sham\u2010operated controls. Blood samples were taken at 6 months preoperatively and postoperatively after to assess luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels for hormonal evaluation. Testicular NO was evaluated by the Griess method, apoptosis by a TUNEL method and inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expressions by immunohistochemical staining. Mild (\u2009+\u2009) eNOS expression was observed in all specimens. Mild (\u2009+\u2009) iNOS expression was only detected in ipsilateral testis of the mesh\u2010implanted study group. Apoptotic cells were not detected in any samples. We are of the opinion that long\u2010term polypropylene mesh implantation has no effect on testicular hormonal function and only a limited effect on nitric oxide levels and this effect is not sufficient to cause apoptosis in testis that could lead to infertility. It seems that mesh implantation is a reliable method in inguinal hernia repair; however, further work is required by more sensitive methods to fully elucidate the potential testicular damage. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1139","type":"journal-article","created":{"date-parts":[[2004,9,17]],"date-time":"2004-09-17T12:00:26Z","timestamp":1095422426000},"page":"213-220","source":"Crossref","is-referenced-by-count":13,"title":["The long\u2010term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis"],"prefix":"10.1002","volume":"23","author":[{"given":"Fatma","family":"Taneli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Aydede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Vatansever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cevval","family":"Ulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeki","family":"Ari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir Sami","family":"Uyan\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70369-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70366-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70365-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/11024159950189726"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427664"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188403"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70371-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada S","year":"1991","journal-title":"Pharmocol Rev"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod55.5.935"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119782"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7162"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.8.1440"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.493"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61681-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00560-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01576157"},{"key":"e_1_2_1_18_2","first-page":"229","article-title":"Color Doppler ultrasound in the assessment of ischemic orchitis after inguinal herniorraphy","volume":"12","author":"Hamilton P","year":"1995","journal-title":"Probl Gen Surg"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.1.13"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.5.1465"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.2.514"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.3.718"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.5.1221"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/01485019808988547"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.1139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.1139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:09:53Z","timestamp":1760040593000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.1139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,17]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/cbf.1139"],"URL":"https:\/\/doi.org\/10.1002\/cbf.1139","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"type":"print","value":"0263-6484"},{"type":"electronic","value":"1099-0844"}],"subject":[],"published":{"date-parts":[[2004,9,17]]}}}