{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:38:13Z","timestamp":1780076293521,"version":"3.54.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T00:00:00Z","timestamp":1090972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate possible protective effects of melatonin on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced renal damage in rats. A total of 24 animals were divided into three equal groups: the control rats received pure olive oil subcutaneously, rats in the second group were injected with CCl<jats:sub>4<\/jats:sub> (0.5\u2009ml\u2009kg<jats:sup>\u22121<\/jats:sup>, s.c. in olive oil) and rats in the third group were injected with CCl<jats:sub>4<\/jats:sub> (0.5\u2009ml\u2009kg<jats:sup>\u22121<\/jats:sup>) plus melatonin (25\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, s.c. in 10% ethanol) every other day for 1 month. At the end of the experimental period, the animals were sacrificed and blood samples were collected. The kidneys were removed and weighed. Urea and creatinine levels were determined in blood samples. Histopathological examination of the kidney was performed using light microscopic methods. Administration of CCl<jats:sub>4<\/jats:sub> significantly increased relative kidney weight (g\u2009per\u2009100\u2009g body weight) and decreased serum urea levels compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Melatonin treatment significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) reduced relative kidney weight, and it produced a statistically equal (<jats:italic>p<\/jats:italic>\u2009=\u20090.268) relative weight with the kidneys of control rats. CCl<jats:sub>4<\/jats:sub> administration alone also caused histopathologically prominent damage in the kidney compared to the control group. Glomerular and tubular degeneration, interstitial mononuclear cell infiltration and fibrosis, vascular congestion around the tubules, and interstitial haemorrhage in perivascular areas were observed in the renal cortex and cortico\u2010medullary border. However, the affect of CCl<jats:sub>4<\/jats:sub> on the medulla was limited. Melatonin provided protection against CCl<jats:sub>4<\/jats:sub>\u2010induced renal toxicity as was evident by histopathological evaluation. In view of the present findings, it is suggested that melatonin protects kidneys against CCl<jats:sub>4<\/jats:sub> toxicity. 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