{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:26Z","timestamp":1760060726086,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,18]],"date-time":"2005-01-18T00:00:00Z","timestamp":1106006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to clarify the effects of <jats:sc>D<\/jats:sc>\u2010penicillamine (DPA), a drug used for treatment of various pathological events, on lung elastin formation and maturation of the newborn in the perinatal period. The investigation was conducted on 20 newborn rats bred from 40 female and six male rats. DPA doses 400\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009day<jats:sup>\u22121<\/jats:sup> and physiological saline were given intraperitoneally (i.p) to experimental and control groups. To assess newborn maturation, their body and lung weights were determined. Serum Cu levels were measured by atomic absorption spectroscopy and ceruloplasmin (Cp) activities were measured spectrophotometrically. Newborn lung tissue elastin, desmosine (DES) and isodesmosine (IDES) levels were measured by HPLC. The results showed that DPA treatment caused loss of skin elasticity and reduction in body and lung weight in newborns of the experimental group. The serum Cu levels and Cp activity were found to be significantly lower in both maternal and newborn of the experimental groups compared with the control group. The lung DES, IDES and elastin values of newborns in the experimental group were decreased compared with the control group. In conclusion, our results indicate that 400\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009day<jats:sup>\u22121<\/jats:sup> DPA, a dose that is used in the treatment of Wilson's disease, rheumatoid arthritis and cystinuria, caused the retardation of newborn maturation, a decrease in DES\u2010IDES cross\u2010links and levels of lung elastin of offspring in the perinatal period. Another conclusion to be drawn from this study is that even low levels of Cu depletion due to DPA administration induces a change in cross\u2010linking in lung elastin during the perinatal period. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1209","type":"journal-article","created":{"date-parts":[[2005,1,18]],"date-time":"2005-01-18T13:21:01Z","timestamp":1106054461000},"page":"167-172","source":"Crossref","is-referenced-by-count":2,"title":["Effect of <scp>D<\/scp>\u2010penicillamine on rat lung elastin cross\u2010linking during the perinatal period"],"prefix":"10.1002","volume":"24","author":[{"given":"Semra","family":"Ko\u00e7t\u00fcrk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclg\u00fcn","family":"Oktay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"G\u00fcner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7etin","family":"Pek\u00e7etin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ataman","family":"G\u00fcre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.22.2787"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199305060-00015"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01813.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050736"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jn\/122.2.355","article-title":"Penicillamine: pharmacokinetics and differential effects on zinc and copper status in chicks","volume":"122","author":"Junxuan LU","year":"1992","journal-title":"J Nutr"},{"key":"e_1_2_1_7_2","first-page":"221","article-title":"Effect of D(\u2212) penicillamine on fetal lungs of rats: a model for congenital emphysema","volume":"31","author":"Yurdak\u00f6k M","year":"1989","journal-title":"Turk J Ped"},{"key":"e_1_2_1_8_2","first-page":"17","article-title":"D\u2010Penicillamine\u2010side effects, pathogenesis and decreasing the risks","volume":"47","author":"Grasedyck K","year":"1988","journal-title":"Z Rheumatol"},{"key":"e_1_2_1_9_2","first-page":"625","article-title":"Transient fetal myelosuppressive effect of D\u2010 penicillamine when used in pregnancy","volume":"55","author":"Yalaz M","year":"2003","journal-title":"Minerva Pediatr"},{"key":"e_1_2_1_10_2","first-page":"521","article-title":"Influence of D\u2010penicillamine on the formation of elastin and its cross\u2010links","volume":"27","author":"Ledvina M","year":"1978","journal-title":"Physiol Bohemoslov"},{"key":"e_1_2_1_11_2","first-page":"L13","article-title":"The regulation of lung elastin synthesis","volume":"259","author":"Foster JA","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1152\/jappl.1971.30.4.508","article-title":"Effect of DL\u2010penicillamine on elastic properties of rat lung","volume":"30","author":"Hoffman L","year":"1971","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1152\/jappl.1972.33.1.42","article-title":"Effect of DL\u2010penicillamine on fibrous proteins of rat lung","volume":"33","author":"Hoffman L","year":"1972","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902148509087806"},{"key":"e_1_2_1_15_2","first-page":"72","article-title":"Lysyl oxidase","volume":"8","author":"Siegel RC","year":"1979","journal-title":"Int Rev Connec Tissue Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0148"},{"key":"e_1_2_1_17_2","first-page":"1","article-title":"Early markers of lung injury","volume":"29","author":"Evans JN","year":"1989","journal-title":"Res Rep Health Eff Inst"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199707)24:1<12::AID-PPUL3>3.0.CO;2-L"},{"key":"e_1_2_1_19_2","first-page":"257","volume-title":"Grundlagen f\u00fcr die Zucht und Haltung der Wichtigsten Versuchstiere","author":"Siegfried J","year":"1962"},{"key":"e_1_2_1_20_2","first-page":"301","volume-title":"Introduction and Overview of Copper as an Element Essential for Life","author":"Linder MC","year":"1991"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(86)90089-2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"S350","DOI":"10.1042\/bst026s350","article-title":"The effects of pre\u2010 and post natal copper depletion on mitochondrial cytochrome oxidase activities of newborn rats","volume":"26","author":"Gezer S","year":"1998","journal-title":"Biochem Soc Trans"},{"key":"e_1_2_1_23_2","first-page":"1","article-title":"The analysis of biological and clinical materials","volume":"4","author":"Delves HT","year":"1981","journal-title":"Prog Anal Atom Spectrosc"},{"key":"e_1_2_1_24_2","first-page":"448","volume-title":"Gradwohl's Clinical Laboratory Methods and Diagnosis","author":"Frankel S","year":"1970"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90151-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)86052-1"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091140404"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90493-6"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008209009006988"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008209309016836"},{"key":"e_1_2_1_31_2","first-page":"17","article-title":"Teratogenic effects of D\u2010penicillamine in rats: relation to copper deficiency","volume":"2","author":"Keen CI","year":"1983","journal-title":"Drug Nutr Interact"},{"key":"e_1_2_1_32_2","first-page":"373","article-title":"Dermal elastin and collagen in systemic sclerosis: effect of D\u2010penicillamine treatment","volume":"7","author":"Pasquali RI","year":"1989","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1880001"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.1.140"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/ajcn\/63.5.791","article-title":"Copper as an essential nutrient","volume":"63","author":"Olivares M","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2290153"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(82)82087-9"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1151"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/jn\/126.1.51","article-title":"Modulation of lysyl oxidase by dietary copper in rats","volume":"126","author":"Rucker RB","year":"1996","journal-title":"J Nutr"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.1209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.1209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:46:19Z","timestamp":1760035579000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,18]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1002\/cbf.1209"],"URL":"https:\/\/doi.org\/10.1002\/cbf.1209","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"type":"print","value":"0263-6484"},{"type":"electronic","value":"1099-0844"}],"subject":[],"published":{"date-parts":[[2005,1,18]]}}}