{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:15:37Z","timestamp":1765545337797,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,2]],"date-time":"2005-09-02T00:00:00Z","timestamp":1125619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid hormones regulate energy metabolism and act on mitochondria which are an important source of free radicals in the cell. The pineal gland activates antioxidant systems via melatonin secretion and thus has a protective function in body tissues. The present study was conducted to determine the oxidative damage caused by hyperthyroidism in kidney and testis tissues of pinealectomized rats. Experimental animals were allocated to three groups: 1, control group; 2, sham pinealectomy\u2010hyperthyroidic group; and 3, pinealectomy\u2010hyperthyroidic group. Hyperthyroidism was induced by A 3\u2010week intraperitoneal administration of thyroxin after sham pinealectomy or pinealectomy. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in kidney and testis tissues. MDA levels of the kidney and testis tissue in the pinealectomy and hyperthyroidic groups were significantly higher than those in the sham pinealectomy\u2010hyperthyroidic group and the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). GSH levels of both kidney and testis tissues were significantly higher in the sham\u2010pinealectomy\u2010hyperthyroidic group when compared to the other two groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). This increase in GSH levels was more evident in the pinealectomy\u2010hyperthyroidic group than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The results of our study demonstrate that MDA and GSH levels in kidney and testis tissues increased due to hyperthyroidism and that pinealectomy made the increase in MDA levels more apparent, while decreasing GSH levels. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1254","type":"journal-article","created":{"date-parts":[[2005,9,2]],"date-time":"2005-09-02T09:16:40Z","timestamp":1125652600000},"page":"449-453","source":"Crossref","is-referenced-by-count":8,"title":["Pinealectomy increases oxidant damage in kidney and testis caused by hyperthyroidism in rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Rasim","family":"Mogulkoc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkerim 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