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Hyaluronidase not only increases the potency of other toxins but also damages the local tissue. In spite of its important role, little attention has been paid to this enzyme. Hyaluronidase exists in various isoforms and generates a wide range of hyaluronic acid degradation products. This suggests that beyond its role as a spreading factor venom hyaluronidase deserves to be explored as a possible therapeutic target for inhibiting the systemic distribution of venom and also for minimizing local tissue destruction at the site of the bite. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1261","type":"journal-article","created":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T06:16:39Z","timestamp":1130134599000},"page":"7-12","source":"Crossref","is-referenced-by-count":151,"title":["Snake venom hyaluronidase: a therapeutic target"],"prefix":"10.1002","volume":"24","author":[{"given":"K.","family":"Kemparaju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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