{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:12:36Z","timestamp":1790021556045,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T00:00:00Z","timestamp":1138579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study aimed to determine the effect of estradiol\u2010progesterone supplementation and pinealectomy on lipid peroxidation of liver tissue in ovariectomized rats.<\/jats:p><jats:p>The study was carried out on 36 adult Sprague\u2010Dawley female rats, which weighed 200\u2013250\u2009g. The rats were divided into 6 groups: Group 1: Sham Ovariectomy (Sham\u2010Ovx), Group 2: Ovariectomy (Ovx), Group 3: Ovx\u2009+\u2009Estradiol\u2010Progesterone supplementation (Ovx\u2009+\u2009H), Group 4: Sham Pinealectomy and Ovx (Sham Pnx \u2010Ovx), Group 5: Ovx \u2010Pnx, Group 6: Ovx \u2010Pnx\u2009+\u2009H. Malondialdehyde (MDA), reduced form of glutathione (GSH) and glutathione peroxidase (GSH\u2010Px) levels were determined in liver tissue of rats.<\/jats:p><jats:p>The highest MDA levels and the lowest GSH\u2010Px levels were determined in the ovariectomized\u2010pinealectomized group, whereas the lowest MDA was in the Sham\u2010Ovx group, and the highest GSH\u2010Px levels were found in the Sham\u2010Ovx and Ovx\u2009+\u2009Hormone supplemented group. Furthermore, the highest GSH levels were in group 1 and lowest levels were in group 5.<\/jats:p><jats:p>The findings of this study demonstrate that ovariectomy led to lipid peroxidation in liver tissues of rats. Pinealectomy in addition to ovariectomy, increases lipid peroxidation, but, estradiol and progesterone supplementations to the ovariectomized\u2010pinealectomized rats protect against lipid peroxidation to a significant extent. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1313","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T05:16:21Z","timestamp":1138598181000},"page":"401-405","source":"Crossref","is-referenced-by-count":23,"title":["Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation"],"prefix":"10.1002","volume":"25","author":[{"given":"Esma","family":"Oztekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Muhtar","family":"Tiftik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkerim 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