{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T20:40:16Z","timestamp":1787517616465,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T00:00:00Z","timestamp":1154476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Testicular torsion is a urological emergency referred to as \u2018acute scrotum\u2019, because inappropriate treatment can lead to male subfertility and infertility. A possible cause of testicular damage is the ischaemia\u2013reperfusion (I\/R) injury attributed to oxygen free radicals. <jats:sc>L<\/jats:sc>\u2010carnitine, a vitamin\u2010like antioxidant, plays a pivotal role in the maturation of spermatozoa within the reproductive tract. The aim of the present paper was to determine the protective effect of <jats:sc>L<\/jats:sc>\u2010carnitine on testicular I\/R\u2010induced injury. Thirty\u2010two male rats were divided into 4 groups (<jats:italic>n<\/jats:italic>\u2009=\u20098). Testicular torsion was created by rotating the right testis 720\u00b0 in a clockwise direction. Group 1: sham\u2010operated control; group 2: ischaemia; group 3: I\/R; group 4: ischaemia\u2013<jats:sc>L<\/jats:sc>\u2010carnitine treatment\u2013reperfusion group. <jats:sc>L<\/jats:sc>\u2010carnitine (500\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, intraperitoneally) was administered before 30 min of detorsion in Group 4. After torsion (5\u2009h) and detorsion (5\u2009h), bilateral orchidectomy was performed. The malondialdehyde (MDA) level was evaluated in testes. Histopathologically, Johnsen's spermatogenesis criteria and mean seminiferous tubule diameter (MSTD) measurements were used. Testicular MDA levels were higher in the torsion group compared to the sham\u2010control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Detorsion (reperfusion) caused a further increase in MDA levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Pretreatment with <jats:sc>L<\/jats:sc>\u2010carnitine prevented a further increase in MDA levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Histologically, torsion caused some separation among germinal cells in the seminiferous tubules, which became much more prominent in the I\/R group but was attenuated with <jats:sc>L<\/jats:sc>\u2010carnitine pretreatment. In conclusion, <jats:sc>L<\/jats:sc>\u2010carnitine pretreatment may have a protective effect in experimental testicular torsion\u2013detorsion model in rats by its well\u2010known antioxidant potential. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.1355","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:37:13Z","timestamp":1154540233000},"page":"611-618","source":"Crossref","is-referenced-by-count":52,"title":["Protective effect of <scp>L<\/scp>\u2010carnitine on testicular ischaemia\u2013reperfusion injury in rats"],"prefix":"10.1002","volume":"25","author":[{"given":"Dikmen","family":"Dokmeci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Inan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit 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